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April 2018. Seattle Magazine Announces Top Docs of 2018
Featuring: Scott Lee, MD; Michael Saunders, MD
Published by: Seattle Magazine
Drs. Scott Lee and Michael Saunders have been recognized in the April 2018 issue of Seattle Magazine. The annual Top Doctors list includes more than 400 doctors in 67 specialties, all nominated by their colleagues for providing exceptional patient care. More than 7,800 nominations were submitted by more than 600 physicians.
April 2018. Dr. George Ioannou Appointed Chair of the AASLD Practice Guidelines Committee
Featuring: George Ioannou, MD, MS
Published by: AASLD
The American Association for the Study of Liver Diseases has appointed Dr. George Ioannou as the new Chair of its Practice Guidelines Committee. AASLD guidelines represent the official opinion of the AASLD and deal with common problem areas for health care practitioners who care for patients with liver disease. The work of the AASLD has laid the foundation for the development of drugs used to treat patients with viral hepatitis. Access to care and support of liver disease research are at the center of AASLD’s advocacy efforts.
March 2018. Dr. Neelendu Dey Inaugrual Recipient of a PAM IRC Innovation Award
Featuring: Neelendu Dey, MD
Published by: Hutch News
Fred Hutch's recently established Pathogen-Associated Malignancies Integrated Research Center (PAM IRC) has handed out its first pilot awards to jump-start innovative research. Dr. Dey will receive $200,000 over two years to investigate the role that the gut microbiome may play in the development of colorectal cancer through its effects on intestinal nerves.
March 2018. Six Misconceptions About Colorectal Cancer
Featuring: Rachel Issaka, MD, MAS; William Grady, MD
Published by: Hutch News
It is the second-most common cancer killer in the U.S., but misconceptions about colorectal cancer can keep people from accessing the preventive care and treatment they might need. Get the facts and lower your risk.
February 2018. CMiST To Begin Hosting Quarterly Seminar Series
Featuring: R. William DePaolo, PhD
Published by: Center for Microbiome Sciences & Therapeutics
One of CMiST's chief goals for 2018 is to begin hosting a quarterly microbiome seminar series that will span across many different fields and disciplines to engage as many researchers, trainees, students and clinicians as possible who are interested in microbiome studies.
February 2018. Before Starting That Diet, Consider Its Effect On Your Gut
Featuring: R. William DePaolo, PhD
Published by: UW Medicine Newsroom
Each year about 45 million Americans go on a diet, but many have no idea that they could be changing their microbiome in the process. While some of the changes can be beneficial, other changes in your gut environment brought about by fad diets can hinder long term efforts to lose weight and result in serious health consequences.
February 2018. Colonoscopy Risks: What is Known and What Are the Next Steps?
Featuring: Cynthia Ko, MD, MS
Published by: Gastroenterology
Colonoscopy is an essential, commonly used tool in gastroenterology, with a primary role in colorectal cancer prevention as well as the diagnosis and management of lower gastrointestinal symptoms. However, colonoscopy is associated with potentially serious complications, and the risk of adverse events has been a topic of extensive study.
January 2018. Obesity and IBD: Diagnostic and Therapeutic Implications
Featuring: Sophia Swanson, MD; Jason Harper, MD; Timothy Zisman, MD, MPH
Published by: Current Opinion in Gastroenterology
The proportion of obese IBD patients is on the rise. This review summarizes our current understanding of how obesity impacts diagnostic studies and therapies in IBD as well as safety and efficacy of medical and surgical weight loss therpaies in the obese IBD patient.
January 2018. Missed Opportunities in Colorectal Cancer Prevention in Patients with Inadequate Bowel Preparations
Featuring: Rachel Issaka, MD, MAS
Published by: Clinical Gastroenterology and Hepatology
Panel management using electronic health records improves patient tracking for various health conditions and health maintenance metrics: altogether, this should improve care quality. Because patients who undergo colonoscopy with an inadequate bowel preparation are invisible when queried by panel management protocols, a recent study aimed to determine the carcinoma rate and advanced neoplasms among FIT-positive patients who rescheduled and completed a colonoscopy following an initial inadequate bowel preparation.
November 2017. Comparing Force Application During Colonoscopy Between Novice and Expert Endoscopists
Featuring: Alexander Ende, MD; Bryan Balmadrid, MD; Joo Ha Hwang, MD, PhD; John Inadomi, MD
Published by: Digestive Diseases and Sciences
Learning to perform colonoscopy safely and effectively is central to gastroenterology fellowship programs. The application of force to the colonoscope is an important part of colonoscopy technique. What are the differences in technique between novice, intermediate and expert endoscopists using the colonoscopy force montior?
November 2017. Provider Interpretations of IBS Food and Symptom Journals
Featuring: Jasmine Zia, MD
Published by: Journal of Clinical Medicine
Up to 65% of patients with IBS associate certain foods with their symptom flare-ups. Identifying personalized trigger foods in food and symptom journals is a commonly accepted management strategy. But how are providers interpreting these results?
November 2017. Large VA Trial Seeks Critical Answers on Colorectal Cancer Screening
Featuring: Jason Dominitz, MD, MHS
Published by: Vantage Point: Official Blog of the VA
The Department of Veterans Affairs has embarked on a landmark study to understand which test is best for colorectal cancer screening. The CONFIRM trial is a large randomized study directly evaluating the two most commonly used approaches to colorectal cancer screening in the United States, colonoscopy vs FIT.
October 2017. What Your Poop Says About Your Health
Featuring: R. William DePaolo, PhD; John Inadomi, MD
Published by: Right As Rain by UW Medicine
Does even the thought of talking about your poop make you blush? It may be uncomfortable, but keeping tabs on your number twos can help you learn a lot about your body. The color and consistency of your poo can change depending on what you eat and drink, and can also serve as your body’s way of letting you know something isn’t right.
October 2017. How Do Diets Affect Gut Health?
Featuring: R. William DePaolo, PhD
Published by: The Whole U
Hoping to take control of your health and overall wellness through a new diet? That’s great news. But as you prepare to embark on any new daily dietary regimen, it’s worth pausing to consider the one component that plays a pivotal role in any such endeavor—and which stands to change the most from it: your microbiome.
October 2017. Editorial: The Name Game - Circumventing Quality Metrics by Categorizing Incomplete Colonoscocpy as Sigmoidoscopy
Featuring: Andrew Kaz, MD; Jason Dominitz, MD, MHS
Published by: The American Journal of Gastroenterology
Cecal intubation rate (CIR) is an important metric for colonoscopy quality. Guidelines propose a minimum CIR of 90% for all indications, and 95% in screening procedures. A recent study of three UK teaching hospitals demonstrated one-third of endoscopists inappropriately converted colonoscopies to flexible sigmoidoscopies, and several endoscopists only reached the 90% CIR benchmark because of these inappropriate conversions.
October 2017. Should You Be Taking Prebiotics for Ulcerative Colitis?
Featuring: R. William DePaolo, PhD
Published by: Everyday Health
If you have ulcerative colitis, chances are you’ve heard of (and may even use) probiotics — supplements of healthy bacteria that promote digestive health and general well-being. But you may not have heard of probiotics' counterpart, prebiotics. By acting as food for helpful bacteria in the gut, prebiotics can contribute to a healthier digestive system.
September 2017. CCFA Touch of Football 2017, UWGI Takes the Win!
Published by: Crohn's & Colitis Foundation of America
On September 16th, 24 local teams competed in a flag football tournament on CenturyLink Field, home of the Seattle Seahawks. This charity event, sponsored by the Crohn's and Colitis Foundation of America, raised more than $181,000 to help find cures for inflammatory bowel disease and support the 1.6 million Americans affected by these diseases. Congratulations to the UWGI team, Game of Crohn's, for taking the win this year! We thank all faculty, fellows and staff who came out to support a good cause.
September 2017. Direct-Acting Hepatitis C Antiviral Treatment in Patients with T2D
Featuring: George Ioannou, MD, MS
Published by: MedPage Today
Researchers at the VA health system—the largest provider of integrated hepatitis C care in the country—recently tested the role of viral eradication on the control of type 2 diabetes (T2D). Previous data demonstrated that the risk of developing T2D is about 4 times higher in people infected with the hepatitis C virus (HCV) than  those without. Investigators wanted to know: Could HCV suppression lead to better control of T2D?
September 2017. Join CMiST for the New Microbiome Club
Featuring: R. William DePaolo, PhD
Published by: Center for Microbiome Sciences & Therapeutics
Hosted by the Center for Microbiome Sciences & Therapeutics, Microbiome Club is an open forum where you can present current and on-going work in a relaxed and comfortable setting. Everyone is encouraged to present - PIs, postdocs and students, too!
September 2017. Top Box Winner, Harborview GI Clinic
Featuring: Joo Ha Hwang, MD, PhD
Congratulations to our gastroenterology clinic at Harborview Medical Center (HMC), winner of the Top Box award for Harborview's Ambulatory Care Division for the 3rd quarter of 2017. This is awarded to the one clinic at HMC with the highest willingness to recommend. Nationally, this ranks our clinic at the 94th percentile. Congratulations to our faculty and staff for their excellent care!
September 2017. Can Direct-Acting Antiviral Agents Reduce the Risk of HCC?
Featuring: George Ioannou, MD, MS
Published by: Journal of Hepatology
It is unclear whether direct-acting antiviral (DAA) treatment-induced sustained virologic response (SVR) reduces the risk of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) infection. A recent study aimed to determine the impact of DAA-induced SVR on HCC risk. Eradication of HCV might be expected to reduce the risk of HCC by preventing the future development of cirrhosis or by reversing early cirrhosis, a major risk factor for HCC. In addition, HCV may itself promote carcinogenesis such that its eradication directly decreases HCC risk.
August 2017. Can Lithium Restore Intestinal Barrier Function in Severe GVHD?
Featuring: Gideon Steinbach, MD; David Hockenbery, MD; George McDonald, MD
Published by: PLoS One
Severe intestinal graft-vs-host disease (GVHD) after allogeneic hematopoietic cell transplantation causes mucosal ulceration and induces innate and adaptive immune responses that amplify and perpetuate GVHD and the associated barrier dysfunction. Pharmacological agents to target mucosal barrier dysfunction in GVHD are needed. A recent pilot study investigated the outcomes of lithium therapy.
August 2017. Improving Efficacy of Chemotherapy Treatment for Pancreatic Cancer
Featuring: Ru Chen, PhD; Teresa Brentnall, MD; Sheng Pan, PhD
Published by: Scientific Reports
Pancreatic cancer is a lethal disease with poor prognosis. Gemcitabine has been the first line systemic treatment for pancreatic cancer. However, the rapid development of drug resistance has been a major hurdle in gemcitabine therapy leading to unsatisfactory patient outcomes. With the recent renewed understanding of glutamine metabolism involvement in drug resistance and immuno-response, a recent study investigated the anti-tumor effect of a glutamine analog as an adjuvant treatment to sensitize chemoresistant pancreatic cancer cells.
July 2017. Congratulations to all of UWGIs Top Doctors of 2017
Featuring: Jason Dominitz, MD, MHS; Joo Ha Hwang, MD, PhD; George Ioannou, MD, MS; Scott Lee, MD; Michael Saunders, MD
Published by: Seattle Metropolitan Magazine
Seattle Metropolitan Magazine conducted its 12th annual survey of the best health care professionals in the Seattle area. Voters were asked, "If you or a loved one needed care, whom would you choose?" Voters nominated their most esteemed peers based on years of experience, competency, rapport with patients, patient satisfaction and compliance with care recommendations, and ability to work effectively with colleagues across specialties to deliver the best patient care. Congratulations to Drs. Jason Dominitz, Joo Ha Hwang, George Ioannou, Scott Lee, and Michael Saunders for making the list.
July 2017. Effectiveness and Cost-Effectiveness of Endoscopic Screening and Surveillance.
Featuring: Nina Saxena, MD; John Inadomi, MD
Published by: Gastrointestinal Endoscopy Clinics of North America
Guidelines for the screening and surveillance of Barrett's esophagus continue to evolve as the incidence of esophageal adenocarcinoma increases, identification of individuals at highest risk for cancer improves, and management of dysplasia evolves. This article reviews related studies and economic analyses. Advances in diagnosis offer promising strategies to help focus screening efforts on those individuals who are most likely to develop esophageal adenocarcinoma.
June 2017. Boiling Histotripsy Treatment of Deep Abdominal Tissue Targets
Featuring: Tatiana Khokhlova, PhD
Published by: Ultrasound in Medicine and Biology
Boiling histotripsy (BH) is a high-intensity focused ultrasound (HIFU)–based method of mechanical tissue fractionation that utilizes millisecond-long bursts of HIFU shock waves to cause boiling at the focus in milliseconds. Multiple clinical applications for BH have been suggested, primarily in oncology, to mechanically ablate unwanted soft tissues. The most relevant applications, in which traditional HIFU is faced with substantial problems, are deep abdominal organ malignancies, including the liver, pancreas and kidney.
June 2017. DAAs Are Effective for Chronic HCV Treatment In Elderly Patients
Featuring: Feng Su, MD; George Ioannou, MD, MS
Published by: European Journal of Gastroenterology & Hepatology
The mean age of patients with chronic hepatitis C virus (HCV) infection in the USA has been increasing. In anticipation of the aging of the HCV-infected population, it is imperative to understand how elderly patients respond to direct-acting antiviral therapy as they will soon constitute the majority of patients receiving treatment.
June 2017. Transition of Pediatric to Adult Care in IBD: Is It As Easy As 1, 2, 3?
Featuring: Anita Afzali, MD, MPH
Published by: World Journal of Gastroenterology
Inflammatory bowel disease (IBD) is a heterogeneous group of chronic diseases with a rising prevalence in the pediatric population, and up to 25% of IBD patients are diagnosed before 18 years of age. Adolescents with IBD tend to have more severe and extensive disease and eventually require graduation from pediatric care toadult services. The transition of patients from pediatric to adult gastroenterologists requires careful preparation and coordination, with involvement of all key players to ensure proper collaboration of care and avoid interruption in care.
May 2017. UW Medicine Top Box Awards
Featuring: Anne Larson, MD; Michael Saunders, MD
Published by: UW Medicine
Congratulations to Dr. Anne Larson (Northwest Hospital Medical Specialites Center) and Dr. Michael Saunders (UWMC Digestive Health Center), who are recipients of a UW Medicine Top Box Award. This award is presented for outpatient willingness to recommend.
May 2017. Predictive Value of Clinical Findings and Plasma Biomarkers After 14 Days of Prednisone Treatment for Acute GVHD
Featuring: George McDonald, MD
Published by: Biology of Blood and Marrow Transplantation
The frequency of acute graft-versus-host-disease (GVHD) after allogeneic hematopoietic cell transplantation is in the 50% to 70% range, with gastrointestinal symptoms the most common presentation. A recent study examines the hypothesis that plasma biomarkers and concomitant clinical findings after initial glucocorticoid therapy can accurately predict failure of GVHD treatment and mortality.
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