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In The News
March 2017. Dr. Will DePaolo Studies Bacteria but His Science Goes Viral
Featuring: R. William DePaolo, PhD
Published by: The Whole U
Dr. William DePaolo, the director of the UW’s new Center for Microbiome Sciences and Therapeutics (CMiST), is highlighted in the Faculty Friday series presented by the Whole U.
November 2016. Does Alcohol and Smoking Increase the Risk of Major GI Bleeding in Men?
Featuring: Lisa Strate, MD, MPH
Published by: PLOS One
Gastrointestinal bleeding (GIB) is a common and potentially life threatening medical problem that accounts for more than 200,000 inpatient admissions and 7,000 deaths in the United States each year. Given the significant morbidity and mortality associated with GIB, it is important to identify potentially modifiable risk factors for GIB, such as smoking and alcohol consumption.
November 2016. Haemopoietic Cell Transplantation in Patient's with Gilbert's Syndrome
Featuring: George McDonald, MD
Published by: The Lancet Haematology
Gilbert's syndrome is a common inherited disorder of bilirubin metabolism, characterised by mild, unconjugated hyperbilirubinaemia. However, the effect of Gilbert's syndrome on the disposition of some drugs can lead to unexpected toxicity. We tested the hypothesis that patients undergoing myeloablative conditioning and haemopoietic cell transplantation would have different mortality outcomes depending on whether or not they had laboratory evidence of Gilbert's syndrome.
October 2016. Obesity and Smoking May Influence DNA Methylation in the Esophagus
Featuring: Andrew Kaz, MD; William Grady, MD
Published by: Clinical Epigenetics
A recent study suggests obesity and tobacco smoking may influence DNA methylation in the esophagus and raise the possibility that these risk factors affect the development of Barrett's esophagus, dysplastic Barrett's, and esophageal adenocarcnima through influencing the epigenetic status of specific loci that have a biologically plausible role in cancer formation.
October 2016. Gastric Intestinal Metaplasia: An Irreversible Risk Factor for Gastric Cancer?
Featuring: Jennifer Higa, MD; Joo Ha Hwang, MD, PhD
Published by: Gastrointestinal Endoscopy
Gastric cancer (GC) remains the fifth most common malignancy globally. This has led to mass screening in certain high-incidence groups, enabling detection of early GC and resulting in an improvement in patient outcomes. In the West, the relatively low incidence of GC has led to the perception that mass screening is impractical, and clear guidelines for GC screening and surveillance are lacking in the United States.
September 2016. Biomarkers for Colitis-Associated Colorectal Cancer
Featuring: Ru Chen, PhD; Teresa Brentnall, MD; Sheng Pan, PhD
Published by: World Journal of Gastroenterology
Patients with extensive ulcerative colitis (UC) of more than eight years duration have an increased risk of colorectal cancer. Molecular biomarkers for dysplasia and cancer could have a great clinical value in managing cancer risk in these UC patients. What are some of the highlights of ongoing avenues of research in biomarker development for colitis-associated colorectal cancer?
September 2016. Interaction of Obesity and Inflammatory Bowel Disease
Featuring: Timothy Zisman, MD, MPH
Published by: World Journal of Gastroenterology
Obesity has emerged as one of the leading global public health issues of the 21st century. Although obesity was once considered uncommon in IBD, the prevalence of obesity in IBD has risen in parallel with the general population. Understanding the interaction between obesity and IBD with regard to disease pathogenesis, phenotypic disease expression and response to therapy has important implications for management.
September 2016. New Antiviral Regimens for the Treatment of HCV Result in Real-World Effectiveness in the VA National Healthcare System
Featuring: George Ioannou, MD, MS
Published by: Gastroenterology
Highly effective, well-tolerated, non-interferon-based antiviral regimens, such as Sofosbuvir, for hepatitis c virus infection were made available for the first time in 2013 and 2014. These regimens were reported in clinical trials to have sustained virologic response (SVR) rates well in excess of 90%. A real-world study of these regimens in the VA national health care system has resulted in remarkably high SVR rates approaching the rates reported in clinical trials.
August 2016. Gallstones: New Insights Into An Old Story
Featuring: Evan Tiderington, MD; Sum Lee, MD, PhD; Cynthia Ko, MD, MS
Published by: F1000Research
Gallstones, particularly cholesterol gallstones, are common in Western populations, and recent studies have allowed for a better understanding of the risks of symptoms or complications. What are the new advances in our understanding of the natural history, clinical associations, and management of gallstone disease?
August 2016. Liver Transplantation for HCC: Improving Prioritization
Featuring: George Ioannou, MD, MS
Published by: Liver Transplantation
Since the introduction of the MELD-based allocation system, the transplant community has been struggling to determine how to best incorporate patients with hepatocellular carcinoma (HCC). The HCC MELD exception system has been adjusted multiple times since 2002 in an attempt to reduce disparities between patients with and without HCC. Recent studies prompt us to critically re-examine the fundamental principles on which the current HCC MELD exception prioritization system is based.
August 2016. Seattle Met Magazine's 2016 Top Doctors
Featuring: Teresa Brentnall, MD; Margaret Eugenio, MD; Joo Ha Hwang, MD, PhD; John Inadomi, MD; Cynthia Ko, MD, MS; Scott Lee, MD
Published by: Seattle Metropolitan Magazine
Seattle Met Mazagine published its 11th annual list of the best health practitioners in the Seattle area, which features 911 doctors, physician assistants, nurse practitioners, and more in 100 specialties. Congratulations to Drs. Teresa Brentnall, Margaret Eugenio, Joo Ha Hwang, John Inadomi, Cynthia Ko, and Scott Lee for making this year's list.
July 2016. Reinduction with Certolizumab Pegol in Patients with Crohn’s Disease
Featuring: Scott Lee, MD
Published by: Inflammatory Bowel Diseases
Crohn’s disease is a lifelong, incurable inflammatory bowel disease of the gastrointestinal tract that often arises in the earlier decades of life and is characterized by periods of exacerbation and remission. Patients in whom anti-TNF therapy fails have limited treatment options. Is there benefit to reintroducing the same therapy?
July 2016. Racial and Ethnic Minorities with IBD in the US
Featuring: Anita Afzali, MD, MPH
Published by: Inflammatory Bowel Diseases
Inflammatory bowel disease has predominantly affected whites, particularly Ashkenazi Jews. Over the last 2 decades, IBD has "emerged" in minorities. Differences in natural history and disease characteristics have been suggested. This systematic review summarizes these differences in studies from the United States.
July 2016. The Changing Faces of Cholangitis
Featuring: Sum Lee, MD, PhD; Joseph Roberts, MD; Rahul Kuver, MD
Published by: F1000Research
The term ‘cholangitis’ taken at face value means inflammation in the biliary system. This simple terminology is deceptive, however, as it encompasses a wide variety of diseases. This review highlights selected advances in cholangitis research that point to novel insights into the pathophysiology, diagnosis, and treatment of this diverse array of disorders.
July 2016. Screening and Surveillance for Gastric Cancer: Is It Needed?
Featuring: Joo Ha Hwang, MD, PhD
Published by: Endoscopedia - Official Blog of Gastrointestinal Endoscopy
The perception of gastric cancer in the US is that it is a relatively uncommon disease and that screening for gastric cancer is not needed. However, most people do not realize that gastric cancer is more common than esophageal cancer in the US. We have clear guidelines on screening for Barrett’s esophagus and esophageal cancer; however, no clear guidelines exist for screening for gastric cancer even though there are populations in the United States that are at high risk for developing gastric cancer.
June 2016. Dr. Anita Afzali Selected as New Chair of the CCFA Medical Advisory Committee
Featuring: Anita Afzali, MD, MPH
Published by: Crohn's and Colitis Foundation of America
We are pleased to announce that Dr. Anita Afzali has been selected as the new Chair of the CCFA Northwest Chapter Medical Advisory Committee. Individuals on this committee provide CCFA staff with invaluable support including insight on issues that are important to their patients, directing their patients to take advantage of CCFA’s services, and act as local liaisons for planning events in their communities. As Chair, Dr. Afzali ensures that value is returned to members in the form of education opportunities, public recognition, and ongoing engagement and appreciation.
June 2016. Dr. Elizabeth Broussard Receives Inaugural Quality and Safety Award
Featuring: Elizabeth Broussard, MD
Published by: DOM Week
Congratulations to Dr. Elizabeth Broussard who has been selected as the inaugural recipient of the Gene Peterson Award for Excellence in Quality Improvement from the UW Housestaff Quality & Safety Committee. This award is named in honor of Dr. Gene Peterson, a pioneer of quality and safety within UW Medicine.
June 2016. Evaluation of a Mindfulness-Based Intervention for Gulf War Illness
Featuring: David Kearney, MD
Published by: DOM Week
Dr. David Kearney has received a VA HSR&D Merit Review research grant, for a clinical trial titled: “Evaluation of a Mindfulness-Based Intervention for Gulf War Illness.” This 4-year trial will assess whether Veterans randomized to a standardized mindfulness intervention report greater reductions in pain, fatigue and cognitive failures at as compared to a rigorously designed control condition (the Chronic Disease Self-Management Program).  
June 2016. Colorectal Cancer Screening, Which Test Is Best?
Featuring: John Inadomi, MD
Published by: JAMA Oncology
80% by 2018 is a movement in which hundreds of organizations have committed to eliminating colorectal cancer as a major public health problem and are working toward the shared goal of reaching 80% screened for colorectal cancer by 2018. However, there are multiple options available for colorectal cancer screening that vary in accuracy, interval, and harms.
June 2016. Upper GI Motility Disorders in Women
Featuring: Jasmine Zia, MD
Published by: Gastroenterology Clinics of North America
Female ovarian hormones are one of the main causes for the observed sex differences in upper gastrointestinal motility. Both estrogen and progesterone receptors are found throughout the GI tract and likely influence its motility.
May 2016. All About Gut Health, What Does Your Gut Tell You?
Featuring: Christina Surawicz, MD
Published by: The Whole U
It takes guts to live in this world. That’s why we have a GI tract. Dr. Christina Surawicz, a leading researcher on the topic, talks to The Whole U about this essential but often overlooked system of digestive organs.
May 2016. Tripartite Pathophysiological Circuit of IBD
Featuring: Stephen Vindigni, MD; Timothy Zisman, MD, MPH; Christopher Damman, MD
Published by: Therapeutic Advances in Gastroenterology
The intestinal microbiome, barrier function, and immune system. Most conventional IBD therapies currently target only one component of the pathophysiological circuit, inflammation; however, many patients do not respond to immune-modulating therapies.
May 2016. UWGI at DDW 2016, May 22-24
Are you attending Digestive Disease Week 2016 in San Diego, California? Access a comprehensive list of faculty and fellows from the University of Washington Division of Gastroenterology who will be presenting their work at this year's conference.
May 2016. Helicobacter Pylori: A Review of Epidemiology, Treatment, and Management
Featuring: Anita Afzali, MD, MPH
Published by: Journal of Clinical Gastroenterology and Treatment
Helicobacter pylori was first isolated in 1983. It was discovered by Marshall and Warren who cultured Campylobacter pyloridis, which was later reclassified as Helicobacter pylori. In the era of antibiotic resistance current treatment options could soon become obsolete; thus new research is focusing on other antibiotic regiments along with vaccine development to combat this pathogen.
May 2016. Physicians Reconnect With Themselves To Lower Stress
Featuring: David Kearney, MD
Published by: UW Health Sciences: Newsbeat
Academic medical centers are known as magnets for suffering, not only for patients but for physicians and healthcare workers working in that world every day. UW Medicine offers doctors and their families mindfulness training four times a year.
May 2016. On the Quality of Quality Metrics: Rethinking What Defines a Good Colonoscopy
Featuring: Jason Dominitz, MD, MHS
Published by: American Journal of Gastroenterology
The colonoscopy quality assurance movement has focused on a variety of process metrics, including the adenoma detection rate (ADR). However, the ADR only ascertains whether or not at least one adenoma is identified. Supplemental measures that quantify all neoplasia have been proposed.
May 2016. Outstanding Consultants of the Month Award
Featuring: Margot Herman, MD; Joseph Roberts, MD; Richard Tobin, MD
Published by: DOM Week
The Outstanding Consultant of the Month Award began in 2015 as a recognition program for consultants (individuals or services) within the Department of Medicine and from other clinical departments at the University of Washington Medical Center (UWMC)
May 2016. Surrogate Markers: Lessons from the Next Gen?
Featuring: Brian Reid, MD, PhD
Published by: Cancer Prevention Research
This editorial addresses a recent randomized control prevention trial of ursodeoxycholic acid in Barrett’s esophagus, which reported a null outcome despite being well designed and executed. Possible reasons for this null outcome are discussed focusing on use of surrogate endpoints in the trial. The trial is especially topical because it comes at a time when there are calls for a Pre-Cancer Genome Atlas (PCGA) for “understanding the earliest molecular and cellular events associated with cancer initiation…”
May 2016. Management of Patients with Acute Lower GI Bleeding
Featuring: Lisa Strate, MD, MPH
Published by: American Journal of Gastroenterology
Gastrointestinal bleeding usually leads to hospital admission with invasive diagnostic evaluations, and consumes significant medical resources. Although most patients with acute LGIB stop bleeding spontaneously and have favorable outcomes, morbidity and mortality are increased in older patients and those with comorbid medical conditions. This ACG clinical guideline provides recommendations for the management of patients with acute overt lower gastrointestinal bleedin
April 2016. Progress in the Earlier Detection of Pancreatic Cancer
Featuring: Teresa Brentnall, MD
Published by: Journal of Clinical Oncology
The difficulty of performing pancreatic cancer surveillance in patients genetically susceptible to familial pancreatic cancer cannot be emphasized enough. The stakes are quite high because precursor lesions are difficult to detect with current imaging.
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