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July 2017. Effectiveness and Cost-Effectiveness of Endoscopic Screening and Surveillance.
Featuring: Nina Saxena, MD; John Inadomi, MD
Published by: Gastrointestinal Endoscopy Clinics of North America
Guidelines for the screening and surveillance of Barrett's esophagus continue to evolve as the incidence of esophageal adenocarcinoma increases, identification of individuals at highest risk for cancer improves, and management of dysplasia evolves. This article reviews related studies and economic analyses. Advances in diagnosis offer promising strategies to help focus screening efforts on those individuals who are most likely to develop esophageal adenocarcinoma.
June 2017. DAAs Are Effective for Chronic HCV Treatment In Elderly Patients
Featuring: Feng Su, MD; George Ioannou, MD, MS
Published by: European Journal of Gastroenterology & Hepatology
The mean age of patients with chronic hepatitis C virus (HCV) infection in the USA has been increasing. In anticipation of the aging of the HCV-infected population, it is imperative to understand how elderly patients respond to direct-acting antiviral therapy as they will soon constitute the majority of patients receiving treatment.
June 2017. Transition of Pediatric to Adult Care in IBD: Is It As Easy As 1, 2, 3?
Featuring: Anita Afzali, MD, MPH
Published by: World Journal of Gastroenterology
Inflammatory bowel disease (IBD) is a heterogeneous group of chronic diseases with a rising prevalence in the pediatric population, and up to 25% of IBD patients are diagnosed before 18 years of age. Adolescents with IBD tend to have more severe and extensive disease and eventually require graduation from pediatric care toadult services. The transition of patients from pediatric to adult gastroenterologists requires careful preparation and coordination, with involvement of all key players to ensure proper collaboration of care and avoid interruption in care.
May 2017. UW Medicine Top Box Awards
Featuring: Anne Larson, MD; Michael Saunders, MD
Published by: UW Medicine
Congratulations to Dr. Anne Larson (Northwest Hospital Medical Specialites Center) and Dr. Michael Saunders (UWMC Digestive Health Center), who are recipients of a UW Medicine Top Box Award. This award is presented for outpatient willingness to recommend.
May 2017. Predictive Value of Clinical Findings and Plasma Biomarkers After 14 Days of Prednisone Treatment for Acute GVHD
Featuring: George McDonald, MD
Published by: Biology of Blood and Marrow Transplantation
The frequency of acute graft-versus-host-disease (GVHD) after allogeneic hematopoietic cell transplantation is in the 50% to 70% range, with gastrointestinal symptoms the most common presentation. A recent study examines the hypothesis that plasma biomarkers and concomitant clinical findings after initial glucocorticoid therapy can accurately predict failure of GVHD treatment and mortality.
May 2017. Gemonics, Endoscopy and Control of Gastroesophageal Cancers: A Perspective
Featuring: Brian Reid, MD, PhD
Published by: Cellular and Molecular Gastroenterology and Hepatology
Esophageal adenocarcinoma (EA) is remarkably similar to gastric adenocarcinoma CIN subtype. Current enthusiasm for endoscopic control of EA has little impact on mortality. Current strategies need to be revisited given emerging evidence that many cancers develop rapidly by punctuated and catastrophic genome evolution.
April 2017. Follow-up of Positive Fecal Test Results: Sooner Is Better, But How Much Better?
Featuring: John Inadomi, MD
Published by: Journal of the American Medical Association (JAMA)
Colonoscopy is the most commonly used colorectal cancer screening test, but it is an invasive procedure and can be both costly and inconvenient for patients. Many patients prefer less-invasive tests. Increased use of the fecal immunochemical test (FIT) has the potential to expand the use of colorectal cancer screening to a broader range of patients. However, the effectiveness of FIT depends on several layers of adherence.
April 2017. Dr. William DePaolo Holder of New Endowed Chair in Gastroenterology
Featuring: R. William DePaolo, PhD
Published by: DOM Week
Dr. William DePaolo, associate professor, has been named holder of the Lynn M. and Michael D. Garvey Endowed Chair in Gastroenterology. This chair was established for candidates who have achieved national recognition in the field of intestinal microbiome research. Dr. DePaolo is director of the Center for Microbiome Sciences & Therapeutics (CMiST) and member of the Center for Innate Immunity and Immune Disease.
April 2017. Outstanding Consultant of the Month Award
Featuring: Sophia Swanson, MD
Published by: DOM Week
Congratulations to Dr. Sophia Swanson, recipient of an Outstanding Consultant of the Month Award. This award began in 2015 as a recognition program for consulants (individuals or services) within the Department of Medicine and from other clinical departments at the University of Washington Medical Center.
April 2017. Transplant-Related Survival Benefit Should Influence Prioritization for Liver Transplantation Especially in Patients with Hepatocellular Carcinoma
Featuring: George Ioannou, MD, MS
Published by: Liver Transplantation
Transplant-related survival benefit is calculated as the difference between life expectancy with transplantation and life expectancy without transplantation. Determining eligibility and prioritization for liver transplantation based on the highest survival benefit is a superior strategy to prioritization based on the highest urgency or the highest utility, because prioritization based on the highest survival benefit maximizes the overall life expectancy of all patients in need of liver transplantation.
April 2017. Are Major Dietary Patterns Associated with Risk of Incident Diverticulitis?
Featuring: Lisa Strate, MD, MPH
Published by: Gastroenterology
Dietary fiber is implicated as a risk factor for diverticulitis. Analyses of dietary patterns may provide information on risk beyond those of individual foods or nutrients. The increasing incidence of diverticulitis has been attributed to changes in diet and lifestyle, predominantly a decrease in dietary fiber consumption.
April 2017. Costs of Providing Infusion Therapy for Patients with IBD
Featuring: Anita Afzali, MD, MPH
Published by: Journal of Medical Economics
Inflammatory bowel disease severely impacts patient quality-of-life. Moderate-to-severe disease is often treated with biologics requiring infusion therapy, adding incremental costs beyond drug costs. A recent study evaluates US hospital-based infusion services costs for treatment of patients receiving infliximab or vedolizumab therapy. As the landscape for reimbursement changes, tools for evaluating the costs of infusion therapy may help hospital administrators make informed choices and weigh trade-offs associated with providing infusion services for IBD patients.
March 2017. Dr. Will DePaolo Studies Bacteria but His Science Goes Viral
Featuring: R. William DePaolo, PhD
Published by: The Whole U
Dr. William DePaolo, the director of the UW’s new Center for Microbiome Sciences and Therapeutics (CMiST), is highlighted in the Faculty Friday series presented by the Whole U.
March 2017. Fecal Microbiota Transplantation: A Rapidly Emerging Field
Featuring: Stephen Vindigni, MD; Christina Surawicz, MD
Published by: Gastroenterology Clinics of North America
Fecal microbiota transplantation (FMT) is the transfer of stool from a healthy donor into the colon of a patient whose disease is a result of an altered microbiome, with the goal of restoring the normal microbiota and thus curing the disease. The most effective and well-studied indication for FMT is recurrent Clostridium difficile infection. The field is rapidly emerging and has become a focus in both the public media and peer-reviewed literature.
March 2017. Seattle Magazine Announces Top Doctors of 2017
Featuring: Richard Tobin, MD
Published by: Seattle Magazine
Congratulations to Dr. Richard Tobin, who made the list for Seattle Magazine's Top Doctors of 2017. Seattle magazine seeks out the names of the best physicians in the Puget Sound region and presents these findings to their readers every year. This year’s Top Docs issue includes 413 doctors in 66 specialties, all nominated by their colleagues and compiled by the highly acclaimed health care research firm Castle Connolly Medical Ltd. Dr. Tobin specializes in colon cancer screening, gastroesophageal reflux disease (GERD), and esophageal disorders. He serves as Director of Gastroenterology at our Eastside Specialty Center location.
February 2017. UWGI Welcomes New Administrator
Featuring: Ryan Clarke,
Published by: DOM Week
We are very pleased to welcome Ryan Clarke as the new Administrator for the Division of Gastroenterology. Ryan comes to us with over eight years combined experience in operations management, business development, and program administration. Most recently he served as the administrator for the Emory University Division of Digestive Diseases and Ambulatory Surgery Operation, with oversight of the Gastroenterology Physician Practice and Outpatient Endoscopy Service for Emory Healthcare in Atlanta, Georgia. He has a bachelor’s degree in health science from Ball State University College of Sciences and Humanities in Muncie, Indiana, a master’s degree in health administration (MHA) from Saint Louis University School of Public Health in Missouri, and is a Fellow in the American College of Healthcare Executives.
February 2017. Anal Intraepithelial Neoplasia
Featuring: Joseph Roberts, MD; Andrew Kaz, MD
Published by: World Journal of Gastrointestinal Oncology
AIN is a premalignant lesion of the anal mucosa that is a precursor to anal cancer. Although anal cancer is relatively uncommon, rates of this malignancy are steadily rising in the United States, and among certain high risk populations the incidence of anal cancer may exceed that of colon cancer.
February 2017. Liver Care Line Welcomes New Faculty and Director
Featuring: Kiran Bambha, MD; Scott Biggins, MD
We are very pleased to welcome Dr. Kiran Bambha and Dr. Scott Biggins as associate professors. Dr. Bambha will provide clinical care to Hepatology and liver transplant patients. Her research focus is on liver transplant outcomes and nonalcoholic steatohepatitis (NASH). Dr. Biggins will be the Liver Care Line Director for UW Medicine and Section Chief of Hepatology. He will provide care at outpatient hepatology clinics, outpatient endoscopy, and inpatient hepatology and liver transplantation consultation at UWMC.
February 2017. Endoscopic Sedation: Who, Which, When?
Featuring: John Inadomi, MD
Published by: American Journal of Gastroenterology
The costs of medical care are rising and media has focused attention on the costs of colonoscopy as a potential cause. A major component of procedural costs is the sedation, which is a combination of the drugs used and who administers them.
February 2017. The Association Between Race/Ethnicity and the Effectiveness of Direct Antiviral Agents for Hepatitis C Virus Infection
Featuring: Feng Su, MD; George Ioannou, MD, MS
Published by: Hepatology
New direct-acting antiviral agents (DAAs) have substantially changed the hepatitis C virus (HCV) treatment landscape. Different racial and ethnic groups in the United States are known to have different responses to traditional, interferon-based HCV regimens. It is not yet clear whether the effectiveness of DAAs varies between racial and ethnic groups.
January 2017. Screening for Colorectal Neoplasia
Featuring: John Inadomi, MD
Published by: New England Journal of Medicine
Colorectal cancer is the third most commonly diagnosed cancer and cause of death from cancer in the United States; however, it can be detected in asymptomatic patients at a curable stage. Multiple strategies are available to screen patients who are at average risk for the development of colorectal cancer. Each strategy has differing characteristics with respect to accuracy, invasiveness, interval, costs, and quality of evidence supporting its use.
January 2017. Symptomatic Pancreatic Duct Stones in the Disconnected Bile Duct
Featuring: Alexander Ende, MD
Published by: Pancreatology
Pancreaticobiliary maljunction refers to the union of the pancreatic and biliary ducts outside of the duodenal wall. Patients are at increased risk of bile duct and gallbladder cancer, likely secondary to pancreatic juice refluxing into the biliary tree, and it is recommended that they undergo biliary diversion.
December 2016. Fellowship Match Day Results Are In!
We are pleased to announce a fantastic group of incoming fellows! The Gastroenterology Fellowship Class of 2017 includes Drs. Daniel Bushyhead from University of Pennsylvania; Jeffrey Jacobs from University of Chicago; Rebecca Kosowicz from Yale University; Alina Kutsenko from Stanford University; Yana Thaker from University of Washington; and Philip Vutien from Rush University. We look forward to welcoming them to our program in July 2017.
December 2016. Management of Post-Liver Transplant Recurrence of Hepatitis C
Featuring: Justin Taylor, MD, MSc; Charles Landis, MD, PhD
Published by: Drugs
Cirrhosis due to chronic hepatitis C (HCV) is the leading indication for liver transplantation in North America and Europe. HCV re-infection post-transplant is nearly universal and if left untreated negatively affects patient and graft survival. In the last 3 years, the promise of the directly acting antivirals for the treatment of HCV has been fulfilled with high sustained viral response rates and a low side effect profile.
December 2016. Women in Leadership: Why So Few and What to Do About It
Featuring: Christina Surawicz, MD
Published by: Journal of the American College of Radiology
The numbers of women in medical school and in medical training have increased dramatically and are near 50% overall, but the number of women who advance to senior and leadership positions is not nearly this high. There are many reasons why the number of women in leadership roles in academic medicine has not kept pace with the number of women entering the field of medicine.
November 2016. A Potential Cure for Veterans with Hepatitis C
Featuring: George Ioannou, MD, MS
Published by: UW Department of Medicine
Research led by Dr. George Ioannou and presented at the American Association for the Study of Liver Diseases meeting suggests the United States Veteran Healthcare Administration could potentially cure almost all U.S. veterans in its care who have hepatitis C within two-to-three years.
November 2016. Glycoproteins and Glycoproteomics in Pancreatic Cancer
Featuring: Sheng Pan, PhD; Teresa Brentnall, MD; Ru Chen, PhD
Published by: World Journal of Gastroenterology
Pancreatic cancer is one of the most deadly cancers, in part because detection of pancreatic cancer is difficult at its early stages when surgical and other treatments are most effective. One approach for developing better diagnostic and therapeutic strategies in pancreatic cancer involves targeting cancer-associated aberrant glycosylation. Recent developments of technology in proteomics and chemical biology have thus stimulated growing interest in elucidating the complex glycosylation events involved in pancreatic adenocarcinoma.
November 2016. Does Alcohol and Smoking Increase the Risk of Major GI Bleeding in Men?
Featuring: Lisa Strate, MD, MPH
Published by: PLOS One
Gastrointestinal bleeding (GIB) is a common and potentially life threatening medical problem that accounts for more than 200,000 inpatient admissions and 7,000 deaths in the United States each year. Given the significant morbidity and mortality associated with GIB, it is important to identify potentially modifiable risk factors for GIB, such as smoking and alcohol consumption.
November 2016. Haemopoietic Cell Transplantation in Patient's with Gilbert's Syndrome
Featuring: George McDonald, MD
Published by: The Lancet Haematology
Gilbert's syndrome is a common inherited disorder of bilirubin metabolism, characterised by mild, unconjugated hyperbilirubinaemia. However, the effect of Gilbert's syndrome on the disposition of some drugs can lead to unexpected toxicity. We tested the hypothesis that patients undergoing myeloablative conditioning and haemopoietic cell transplantation would have different mortality outcomes depending on whether or not they had laboratory evidence of Gilbert's syndrome.
October 2016. Obesity and Smoking May Influence DNA Methylation in the Esophagus
Featuring: Andrew Kaz, MD; William Grady, MD
Published by: Clinical Epigenetics
A recent study suggests obesity and tobacco smoking may influence DNA methylation in the esophagus and raise the possibility that these risk factors affect the development of Barrett's esophagus, dysplastic Barrett's, and esophageal adenocarcnima through influencing the epigenetic status of specific loci that have a biologically plausible role in cancer formation.
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