UW Gastroenterology Biosample Repository and Research Registries succeed with your donation!
Patients consenting for investigator access to clinical data variable s and/or biospecimen donations to our Biorepository and Research Registries accelerate our quest for cures. Thanks for considering collaborating with the University of Washington in research and please discuss with our coordinators at your next clinic visit or contact firstname.lastname@example.org! See a recent newsletter of current initiatives.
Financial contributions to the Haggitt Endowed Chair are another means to contribute to these endeavors.
Internal UW research collaborators may submit proposals for: extant biosamples, prospective sample collection initiatives, and data abstraction to GI research enclave. External submittors please complete GICaRes_SampleData_AcquisitionProposal_Request_v2.docx and submit to above address.
Representative current and ongoing collaborations and publications supported by UWGI Biorepository:
Genome Quebec (DbGaP certified contributing partner)
Deriving a living organoid biobank of colon organoids for future investigation
Mucosal-adherent microbiome studies in colorectal cancer in collaboration with Cynthia Ko and Will Depaulo Lab UW.
Liver studies with George Ioannou (VA Seattle) and Charles Landis, and Susan Fink (Laboratory Medicine).
Prospective sample collection for Teri Brentnall (pancreas) and John Inadomi (MEMO) and Chris Goss (Cystic Fibrosis).
Prospective sample collection for Ru Chen (pancolitis) with Tim Zisman.
Novel non-invasive upper endoscopy cytology sample collection devices (sponge and inflatable balloon) and biomarker panel development with Amitabh Chak (Case Western Reserve).
GLNE Validation and Comparison of biomarkers for the Early Detectionof Colorectal Adenocarcinoma collaborating with University of Michigan
Clinical Trial recruitment for Familial Adenomatous Polyposis etiopathology (colorectal cancer precursor) utilization of off-label treatment trial for efficacy response utilizing monoclonal antibody (IL-23/IL-17/JAK/STAT3 pathway)
Collaboration with UW Department of Pathology and NorthWest BioTrust for registry consenting future contact and use of discarded specimens.
Accessioning of historical liver tissue samples into biobank.
Population level data collation for investigators across division and departments: demographics, text reports and variables enabling translational research. Correlation and banking of clinical phenotypes with curated molecular data sets.
Barault L, Amatu A, Siravegna G, Ponzetti A, Moran S, Cassingena A, Mussolin B, Falcomatà C, Binder AM, Cristiano C, Oddo D, Guarrera S, Cancelliere C, Bustreo S, Bencardino K, Maden S, Vanzati A, Zavattari P, Matullo G, Truini M, Grady WM, Racca P, Michels KB, Siena S, Esteller M, Bardelli A, Sartore-Bianchi A, Di Nicolantonio F. Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer. Gut. 2017 Oct 5. pii: gutjnl-2016-313372. doi: 10.1136/gutjnl-2016-313372. [Epub ahead of print PMID: 28982739
D. Edmonds et al. Discovery and assessment of senescence associated factors that may promote colorectal cancer formation. DDW 2018
Cui J, Cai Y, Hu Y, Huang Z, Luo Y, Kaz AM, Yang Z, Chen D, Fan X, Grady WM, Wang J. Epigenetic silencing of TPM2 contributes to colorectal cancer progression upon RhoA activation.Tumour Biol. 2016 Sep;37(9):12477-12483. Epub 2016 Jun 23.PMID:27333992]
Yu M, Carter KT, Makar KW, Vickers K, Ulrich CM, Schoen RE, Brenner D, Markowitz SD, Grady WM. Methylight digital droplet PCR for detection and absolute quantification of infrequent methylated alleles. Epigenetics. 2015 Sep 2;10(9):803-9..PMID:26186366
Kaz AM, Wong C-J, Dzieciatowski S, Luo YX, Schoen RE, Grady WM. Patterns of DNA methylation in the normal colon vary by anatomical location, gender, and age. Epigenetics. 2014 Apr;9(4):492-502.
Luo Y, Wong CJ, Kaz AM, Morris SM, Dzieciatkowski S, Carter KT, Wang J, Willis JE, Makar KW, Ulrich CM, Lutterbaugh JD, Shrubsole MJ, Zheng W, Markowitz SD, Grady WM. Global DNA Methylation Alterations Reveal Multiple Pathways in the Initiation and Progression of Colorectal Cancer. Gastroenterology. 2014 Aug;147(2):418-29.e8
Luo Y, Kaz AM, Kanngurn S, Welsch P, Moris SM, Wang JP, Lutterbaugh JD, Markowitz SD, Grady WM. NTRK3 is a potential tumor suppressor gene commonly inactivated by epigenetic mechanisms in colorectal cancer. PLoS Genetics 2013. Jul; 9(7):epub. PMID 23874207
Canadian Tissue Repository Network biobank directory listing for UWGI Biobank
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Please consider joining our team as participants or contributers to the Fred Hutch mission and the 2019 raffle directly at the link-
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