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Andrew M. Kaz, MD
Assistant Professor
Biography

Dr. Kaz is an assistant professor in the Department of Medicine in Division of Gastroenterology at the University of Washington. He primarily sees patients at the Puget Sound VA Medical Center in Seattle. His professional interests include molecular alterations in Barrett’s esophagus and colon cancer and colon cancer screening. He is board certified in gastroenterology.

Recent Publications
Displaying 20 Most Recent Publications from PubMed

October 2018. Implications of epigenetic drift in colorectal neoplasia. Luebeck GE, Hazelton WD, Curtius K, Maden SK, Yu M, Carter KT, Burke W, Lampe PD, Li CI, Ulrich CM, Newcomb PA, Westerhoff M, Kaz AM, Luo Y, Inadomi JM, Grady WM. Cancer Res. 2018 Oct 5. pii: canres.1682.2018. doi: 10.1158/0008-5472.CAN-18-1682. [Epub ahead of print]

June 2018. Subtypes of Barrett's oesophagus and oesophageal adenocarcinoma based on genome-wide methylation analysis. Yu M, Maden SK, Stachler M, Kaz AM, Ayers J, Guo Y, Carter KT, Willbanks A, Heinzerling TJ, O'Leary RM, Xu X, Bass A, Chandar AK, Chak A, Elliott R, Willis JE, Markowitz SD, Grady WM. Gut. 2018 Jun 8. pii: gutjnl-2017-314544. doi: 10.1136/gutjnl-2017-314544. [Epub ahead of print]

October 2017. Editorial: The Name Game: Circumventing Quality Metrics by Categorizing Incomplete Colonoscopy as Sigmoidoscopy. Kaz AM, Dominitz JA. Am J Gastroenterol. 2017 Oct;112(10):1553-1555. doi: 10.1038/ajg.2017.258.

May 2017. BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis. Parang B, Kaz AM, Barrett CW, Short SP, Ning W, Keating CE, Mittal MK, Naik RD, Washington MK, Revetta FL, Smith JJ, Chen X, Wilson KT, Brand T, Bader DM, Tansey WP, Chen R, Brentnall TA, Grady WM, Williams CS. Gut. 2017 May;66(5):852-862. doi: 10.1136/gutjnl-2015-310255. Epub 2016 Jan 14.

March 2017. Erratum to: Global DNA methylation patterns in Barrett's esophagus, dysplastic Barrett's, and esophageal adenocarcinoma are associated with BMI, gender, and tobacco use. Kaz AM, Wong CJ, Varadan V, Willis JE, Chak A, Grady WM. Clin Epigenetics. 2017 Mar 1;9:23. doi: 10.1186/s13148-017-0324-8.

February 2017. Anal intraepithelial neoplasia: A review of diagnosis and management. Roberts JR, Siekas LL, Kaz AM. World J Gastrointest Oncol. 2017 Feb 15;9(2):50-61. doi: 10.4251/wjgo.v9.i2.50.

October 2016. Global DNA methylation patterns in Barrett's esophagus, dysplastic Barrett's, and esophageal adenocarcinoma are associated with BMI, gender, and tobacco use. Kaz AM, Wong CJ, Varadan V, Willis JE, Chak A, Grady WM. Clin Epigenetics. 2016 Oct 27;8:111.

September 2016. Epigenetic silencing of TPM2 contributes to colorectal cancer progression upon RhoA activation. Cui J, Cai Y, Hu Y, Huang Z, Luo Y, Kaz AM, Yang Z, Chen D, Fan X, Grady WM, Wang J. Tumour Biol. 2016 Sep;37(9):12477-12483. Epub 2016 Jun 23.

September 2016. Comprehensive site-specific whole genome profiling of stromal and epithelial colonic gene signatures in human sigmoid colon and rectal tissue. Knight JM, Kim E, Ivanov I, Davidson LA, Goldsby JS, Hullar MA, Randolph TW, Kaz AM, Levy L, Lampe J, Chapkin RS. Physiol Genomics. 2016 Sep 1;48(9):651-9. doi: 10.1152/physiolgenomics.00023.2016. Epub 2016 Jul 8.

May 2016. A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett's Esophagus. Curtius K, Wong CJ, Hazelton WD, Kaz AM, Chak A, Willis JE, Grady WM, Luebeck EG. PLoS Comput Biol. 2016 May 11;12(5):e1004919. doi: 10.1371/journal.pcbi.1004919. eCollection 2016 May.

April 2016. Use of a novel polyp "ruler snare" improves estimation of colon polyp size. Kaz AM, Anwar A, O'Neill DR, Dominitz JA. Gastrointest Endosc. 2016 Apr;83(4):812-6. doi: 10.1016/j.gie.2015.08.082. Epub 2015 Sep 14.

April 2016. Universal Screening of Colorectal Cancers for Lynch Syndrome: Challenges and Opportunities. Vindigni SM, Kaz AM. Dig Dis Sci. 2016 Apr;61(4):969-76. doi: 10.1007/s10620-015-3964-6. Epub 2015 Nov 24.

January 2016. Can individuals with colonic polyposis be managed safely with colonoscopic surveillance? Kaz AM, Dominitz JA. Endoscopy. 2016 Jan;48(1):7-8. doi: 10.1055/s-0034-1393637. Epub 2015 Dec 28.

December 2015. Methylated B3GAT2 and ZNF793 are potential detection biomarkers for Barrett's esophagus. Yu M, O'Leary RM, Kaz AM, Morris SM, Carter KT, Chak A, Chandar A, Willis JE, Moinova HR, Markowitz SD, Brenner DE, Anandabapasathy S, Westerhoff M, Wong CJ, Shaheen NJ, Chen Y, Barnholtz-Sloan JS, Grady WM. Cancer Epidemiol Biomarkers Prev. 2015 Dec;24(12):1890-7. doi: 10.1158/1055-9965.EPI-15-0370. Epub 2015 Nov 6.

June 2015. Genetic and Epigenetic Alterations in Barrett's Esophagus and Esophageal Adenocarcinoma. Kaz AM, Grady WM, Stachler MD, Bass AJ. Gastroenterol Clin North Am. 2015 Jun;44(2):473-489. doi: 10.1016/j.gtc.2015.02.015. Epub 2015 Apr 1. Review.

August 2014. Differences in DNA Methylation Signatures Reveal Multiple Pathways of Progression from Adenoma to Colorectal Cancer. Luo Y, Wong CJ, Kaz AM, Dzieciatkowski S, Carter KT, Morris SM, Wang J, Willis JE, Makar KW, Ulrich CM, Lutterbaugh JD, Shrubsole MJ, Zheng W, Markowitz SD, Grady WM. Gastroenterology. 2014 Aug;147(2):418-29.e8. doi: 10.1053/j.gastro.2014.04.039. Epub 2014 Apr 30.

April 2014. Patterns of DNA methylation in the normal colon vary by anatomical location, gender, and age. Kaz AM, Wong CJ, Dzieciatkowski S, Luo Y, Schoen RE, Grady WM. Epigenetics. 2014 Apr;9(4):492-502. doi: 10.4161/epi.27650. Epub 2014 Jan 10.

January 2014. Epigenetic biomarkers in esophageal cancer. Kaz AM, Grady WM. Cancer Lett. 2014 Jan 28;342(2):193-9. doi: 10.1016/j.canlet.2012.02.036. Epub 2012 Mar 7.

July 2013. NTRK3 Is a Potential Tumor Suppressor Gene Commonly Inactivated by Epigenetic Mechanisms in Colorectal Cancer. Luo Y, Kaz AM, Kanngurn S, Welsch P, Morris SM, Wang J, Lutterbaugh JD, Markowitz SD, Grady WM. PLoS Genet. 2013 Jul;9(7):e1003552. doi: 10.1371/journal.pgen.1003552. Epub 2013 Jul 11.

April 2012. Aberrantly methylated PKP1 in the progression of Barrett's esophagus to esophageal adenocarcinoma. Kaz AM, Luo Y, Dzieciatkowski S, Chak A, Willis JE, Upton MP, Leidner RS, Grady WM. Genes Chromosomes Cancer. 2012 Apr;51(4):384-93. doi: 10.1002/gcc.21923. Epub 2011 Dec 14.

December 2011. DNA methylation profiling in Barrett's esophagus and esophageal adenocarcinoma reveals unique methylation signatures and molecular subclasses. Kaz AM, Wong CJ, Luo Y, Virgin JB, Washington MK, Willis JE, Leidner RS, Chak A, Grady WM. Epigenetics. 2011 Dec 1;6(12):1403-12.

June 2008. Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer. Grady WM, Parkin RK, Mitchell PS, Lee JH, Kim YH, Tsuchiya KD, Washington MK, Paraskeva C, Willson JK, Kaz AM, Kroh EM, Allen A, Fritz BR, Markowitz SD, Tewari M Oncogene. 2008 Jun 19;27(27):3880-8. Epub 2008 Feb 11

May 2007. Evidence for the role of aberrant DNA methylation in the pathogenesis of Lynch syndrome adenomas. Kaz A, Kim YH, Dzieciatkowski S, Lynch H, Watson P, Kay Washington M, Lin L, Grady WM Int J Cancer. 2007 May 1;120(9):1922-9.

December 2006. Genetic testing for colon cancer. Kaz AM, Brentnall TA Nat Clin Pract Gastroenterol Hepatol. 2006 Dec;3(12):670-9

November 2005. Chimeric Ad5 vectors expressing the short fiber of Ad41 show reduced affinity for human intestinal epithelium. Kesisoglou F, Chamberlain JR, Schmiedlin-Ren P, Kaz A, Fleisher D, Roessler B, Zimmermann EM. Mol Pharm. 2005 Nov-Dec;2(6):500-8.

May 2005. Oxygen regulation of tumor perfusion by S-nitrosohemoglobin reveals a pressor activity of nitric oxide. Sonveaux P, Kaz AM, Snyder SA, Richardson RA, Cárdenas-Navia LI, Braun RD, Pawloski JR, Tozer GM, Bonaventura J, McMahon TJ, Stamler JS, Dewhirst MW. Circ Res. 2005 May 27;96(10):1119-26. Epub 2005 May 5.

February 2004. Protein kinase A regulates ATP hydrolysis and dimerization by a CFTR (cystic fibrosis transmembrane conductance regulator) domain. Howell LD, Borchardt R, Kole J, Kaz AM, Randak C, Cohn JA. Biochem J. 2004 Feb 15;378(Pt 1):151-9.

Contact Info
Education

M.D., Duke University, Durham, NC

Residency, University of Michigan, Ann Arbor, MI

Fellowship, University of Washington, Seattle, WA

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