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Gideon Steinbach, MD
Associate Professor & Associate Member, Fred Hutchinson Cancer Research Center
Biography

Dr. Steinbach's research is focused on gastrointestinal cancer prevention, including genetic and clinical predisposition, chemoprevention, and early detection. The work is based on multidisciplinary and inter-institutional collaborations. Recent collaborative studies investigated the role of aspirin in the prevention of colorectal adenomatous polyps in persons with previous colorectal tumors and the effect of cyclooxygenase-2 inhibition on colorectal adenomatous polyps in patients with FAP (an inherited predisposition to colorectal adenomas). The latter was the first clinical trial to investigate the effect of COX-2 inhibition on a human tumor. Demonstration of efficacy on adenomatous polyps in FAP provided support for initiating trials of COX-2 inhibition for the control of sporadic colon tumors and other tumors that express COX-2.

Recent Publications
Displaying 20 Most Recent Publications from PubMed

August 2018. Fatal enteric plexus neuropathy after one dose of ipilimumab plus nivolumab: a case report. Appelbaum J, Wells D, Hiatt JB, Steinbach G, Stewart FM, Thomas H, Nghiem P, Kapur RP, Thompson JA, Bhatia S. J Immunother Cancer. 2018 Aug 31;6(1):82. doi: 10.1186/s40425-018-0396-9.

September 2017. Graft-versus-Host Disease of the Gut: A Histologic Activity Grading System and Validation. Myerson D, Steinbach G, Gooley TA, Shulman HM. Biol Blood Marrow Transplant. 2017 Sep;23(9):1573-1579. doi: 10.1016/j.bbmt.2017.05.017. Epub 2017 May 19.

August 2017. Pilot study of lithium to restore intestinal barrier function in severe graft-versus-host disease. Steinbach G, Hockenbery DM, Huls G, Furlong T, Myerson D, Loeb KR, Fann JR, Castilla-Llorente C, McDonald GB, Martin PJ. PLoS One. 2017 Aug 17;12(8):e0183284. doi: 10.1371/journal.pone.0183284. eCollection 2017.

August 2016. Genetic/Familial High-Risk Assessment: Colorectal Version 1.2016, NCCN Clinical Practice Guidelines in Oncology. Provenzale D, Gupta S, Ahnen DJ, Bray T, Cannon JA, Cooper G, David DS, Early DS, Erwin D, Ford JM, Giardiello FM, Grady W, Halverson AL, Hamilton SR, Hampel H, Ismail MK, Klapman JB, Larson DW, Lazenby AJ, Lynch PM, Mayer RJ, Ness RM, Regenbogen SE, Samadder NJ, Shike M, Steinbach G, Weinberg D, Dwyer M, Darlow S. J Natl Compr Canc Netw. 2016 Aug;14(8):1010-30.

March 2016. Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure. Richardson PG, Riches ML, Kernan NA, Brochstein JA, Mineishi S, Termuhlen AM, Arai S, Grupp SA, Guinan EC, Martin PL, Steinbach G, Krishnan A, Nemecek ER, Giralt S, Rodriguez T, Duerst R, Doyle J, Antin JH, Smith A, Lehmann L, Champlin R, Gillio A, Bajwa R, D'Agostino RB Sr, Massaro J, Warren D, Miloslavsky M, Hume RL, Iacobelli M, Nejadnik B, Hannah AL, Soiffer RJ. Blood. 2016 Mar 31;127(13):1656-65. doi: 10.1182/blood-2015-10-676924. Epub 2016 Jan 29.

August 2015. Colorectal Cancer Screening, Version 1.2015. Provenzale D, Jasperson K, Ahnen DJ, Aslanian H, Bray T, Cannon JA, David DS, Early DS, Erwin D, Ford JM, Giardiello FM, Gupta S, Halverson AL, Hamilton SR, Hampel H, Ismail MK, Klapman JB, Larson DW, Lazenby AJ, Lynch PM, Mayer RJ, Ness RM, Rao MS, Regenbogen SE, Shike M, Steinbach G, Weinberg D, Dwyer MA, Freedman-Cass DA, Darlow S. J Natl Compr Canc Netw. 2015 Aug;13(8):959-68.

December 2013. Colorectal cancer screening. Burt RW, Cannon JA, David DS, Early DS, Ford JM, Giardiello FM, Halverson AL, Hamilton SR, Hampel H, Ismail MK, Jasperson K, Klapman JB, Lazenby AJ, Lynch PM, Mayer RJ, Ness RM, Provenzale D, Rao MS, Shike M, Steinbach G, Terdiman JP, Weinberg D, Dwyer M, Freedman-Cass D. J Natl Compr Canc Netw. 2013 Dec 1;11(12):1538-75.

July 2013. Comprehensive assessment of HIV target cells in the distal human gut suggests increasing HIV susceptibility toward the anus. McElrath M, Smythe K, Randolph-Habecker J, Melton K, Goodpaster T, Hughes S, Mack M, Sato A, Diaz G, Steinbach G, Novak R, Curlin M, Lord J, Maenza J, Duerr A, Frahm N, Hladik F; the NIAID HIV Vaccine Trials Network. J Acquir Immune Defic Syndr. 2013 Jul 1;63(3):263-71. doi: 10.1097/QAI.0b013e3182898392.

April 2011. Blood and Gastric FOXP3+ T Cells Are Not Decreased in Human Gastric Graft Versus Host Disease. Lord JD, Hackman RC, Gooley TA, Wood BL, Moklebust AC, Hockenbery DM, Steinbach G, Ziegler SF, McDonald GB. Biol Blood Marrow Transplant. 2011 Apr;17(4):486-96. Epub 2010 Sep 24.

February 2011. Hepatic Adenomas Caused by Somatic HNF1A Mutations in Children With Biallelic Mismatch Repair Gene Mutations. Holter S, Pollett A, Zogopoulos G, Kim H, Schwenter F, Asai K, Gallinger S, Clendenning M, Steinbach G, Jacobson A, Boycott KM. Gastroenterology. 2011 Feb;140(2):735-6. Epub 2010 Dec 21.

May 2010. Refractory colitis following anti-CTLA4 antibody therapy: analysis of mucosal FOXP3+ T cells. Lord JD, Hackman RC, Moklebust A, Thompson JA, Higano CS, Chielens D, Steinbach G, McDonald GB. Dig Dis Sci. 2010 May;55(5):1396-405. Epub 2009 Jun 9.

February 2010. Defibrotide for the treatment of severe hepatic veno-occlusive disease and multiorgan failure after stem cell transplantation: a multicenter, randomized, dose-finding trial. Richardson PG, Soiffer RJ, Antin JH, Uno H, Jin Z, Kurtzberg J, Martin PL, Steinbach G, Murray KF, Vogelsang GB, Chen AR, Krishnan A, Kernan NA, Avigan DE, Spitzer TR, Shulman HM, Di Salvo DN, Revta C, Warren D, Momtaz P, Bradwin G, Wei LJ, Iacobelli M, M Biol Blood Marrow Transplant. 2010 Jul;16(7):1005-17. Epub 2010 Feb 16.

January 2010. NCCN clinical practice guidelines in oncology. Colorectal cancer screening. Burt RW, Barthel JS, Dunn KB, David DS, Drelichman E, Ford JM, Giardiello FM, Gruber SB, Halverson AL, Hamilton SR, Ismail MK, Jasperson K, Lazenby AJ, Lynch PM, Martin EW Jr, Mayer RJ, Ness RM, Provenzale D, Rao MS, Shike M, Steinbach G, Terdiman JP, Wei J Natl Compr Canc Netw. 2010 Jan;8(1):8-61.

January 2006. Efficacy of neodymium:YAG laser therapy for gastric antral vascular ectasia (GAVE) following hematopoietic cell transplant. Selinger RR, McDonald GB, Hockenbery DM, Steinbach G, Kimmey MB Bone Marrow Transplant. 2006 Jan;37(2):191-7

March 2003. A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. Sandler RS, Halabi S, Baron JA, Budinger S, Paskett E, Keresztes R, Petrelli N, Pipas JM, Karp DD, Loprinzi CL, Steinbach G, Schilsky R. N Engl J Med. 2003 Mar 6;348(10):883-90.

June 2002. A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis. Phillips RK, Wallace MH, Lynch PM, Hawk E, Gordon GB, Saunders BP, Wakabayashi N, Shen Y, Zimmerman S, Godio L, Rodrigues-Bigas M, Su LK, Sherman J, Kelloff G, Levin B, Steinbach G; FAP Study Group. Gut. 2002 Jun;50(6):857-60.

September 2000. Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis. Su LK, Barnes CJ, Yao W, Qi Y, Lynch PM, Steinbach G. Am J Hum Genet. 2000 Sep;67(3):582-90. Epub 2000 Aug 3.

June 2000. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. Steinbach G, Lynch PM, Phillips RK, Wallace MH, Hawk E, Gordon GB, Wakabayashi N, Saunders B, Shen Y, Fujimura T, Su LK, Levin B, Godio L, Patterson S, Rodriguez-Bigas MA, Jester SL, King KL, Schumacher M, Abbruzzese J, DuBois RN, Hittelman WN, Zimmerman N Engl J Med. 2000 Jun 29;342(26):1946-52.

January 2000. Genomic rearrangements of the APC tumor-suppressor gene in familial adenomatous polyposis. Su LK, Steinbach G, Sawyer JC, Hindi M, Ward PA, Lynch PM. Hum Genet. 2000 Jan;106(1):101-7.

July 1999. Antibiotic treatment of gastric lymphoma of mucosa-associated lymphoid tissue. An uncontrolled trial. Steinbach G, Ford R, Glober G, Sample D, Hagemeister FB, Lynch PM, McLaughlin PW, Rodriguez MA, Romaguera JE, Sarris AH, Younes A, Luthra R, Manning JT, Johnson CM, Lahoti S, Shen Y, Lee JE, Winn RJ, Genta RM, Graham DY, Cabanillas FF. Ann Intern Med. 1999 Jul 20;131(2):88-95.

January 1999. Regulation of cyclooxygenase-2 pathway by HER2 receptor. Vadlamudi R, Mandal M, Adam L, Steinbach G, Mendelsohn J, Kumar R. Oncogene. 1999 Jan 14;18(2):305-14.

October 1998. Microflora of gastric biopsies from patients with duodenal ulcer and gastric cancer: a comparative study of patients from Korea, Colombia, and the United States. Osato MS, Gutierrez O, Kim JG, Steinbach G, Graham DY. Dig Dis Sci. 1998 Oct;43(10):2291-5.

July 1997. S phase determination in intact colonic crypts by histone H3 messenger RNA in situ hybridization and confocal microscopy. Konishi H, Steinbach G, Terry NH, Fujita K, Lee JJ, Ruifrok A, Spaulding D, Lynch PM, Dubin JA, Andreeff M, Goodacre AM, Hattori T, Hittelman WN. Cancer Epidemiol Biomarkers Prev. 1997 Jul;6(7):531-6.

December 1996. Participants' perceptions of a phase I colon cancer chemoprevention trial. Hudmon KS, Stoltzfus C, Chamberlain RM, Lorimor RJ, Steinbach G, Winn RJ. Control Clin Trials. 1996 Dec;17(6):494-508.

June 1996. Calcium carbonate treatment of diarrhoea in intestinal bypass patients. Steinbach G, Lupton J, Reddy BS, Lee JJ, Kral JG, Holt PR. Eur J Gastroenterol Hepatol. 1996 Jun;8(6):559-62.

May 1996. Calcium supplementation modifies the relative amounts of bile acids in bile and affects key aspects of human colon physiology. Lupton JR, Steinbach G, Chang WC, O'Brien BC, Wiese S, Stoltzfus CL, Glober GA, Wargovich MJ, McPherson RS, Winn RJ. J Nutr. 1996 May;126(5):1421-8.

February 1996. Histone H3 messenger RNA in situ hybridization correlates with in vivo bromodeoxyuridine labeling of S-phase cells in rat colonic epithelium. Konishi H, Steinbach G, Terry NH, Lee JJ, Dubin JA, Glober GA, Fujita K, Spaulding D, Cass L, Hittelman WN. Cancer Res. 1996 Feb 1;56(3):434-7.

September 1995. Early detection of esophageal cancer by chromoendoscopy. Steinbach G, Hong WK. Cancer. 1995 Sep 15;76(6):919-21.

December 1994. Regression of gastric lymphoma of mucosa-associated lymphoid tissue with antibiotic therapy for Helicobacter pylori. Weber DM, Dimopoulos MA, Anandu DP, Pugh WC, Steinbach G. Gastroenterology. 1994 Dec;107(6):1835-8.

May 1994. Effect of calcium supplementation on rectal epithelial hyperproliferation in intestinal bypass subjects. Steinbach G, Lupton J, Reddy BS, Kral JG, Holt PR. Gastroenterology. 1994 May;106(5):1162-7.

Contact Info
Education

M.D., Albert Einstein College of Medicine, New York, NY

Residency in Medicine, Columbia University, New York, NY

Fellowship in Gastroenterology, Columbia University, New York, NY

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