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William M. Grady, MD
Professor & Member,
Fred Hutchinson Cancer Research Center
Biography

Dr. Grady specializes in gastroenterology and internal medicine. His particular clinical interests include the diagnosis and treatment of hereditary cancer syndromes, as well as the development and use of molecular markers for the prevention and treatment of colon, esophageal and stomach cancer.

He received his medical degree from the University of Michigan Medical School and was the internal medicine chief resident at the University of Washington School of Medicine. He did his gastroenterology fellowship at Case Western Reserve University and then was on faculty at Vanderbilt University before moving to Seattle.
 
He is currently the UW Rodger C. Haggitt professor of medicine and director of translational research of the gastroenterology section at UWMC. He is also a full member of the Fred Hutchinson Cancer Research Center, Clinical Research Division and the medical director of the GI Cancer Prevention Program Clinic at the Seattle Cancer Care Alliance.
 
Recent Publications
Displaying 20 Most Recent Publications from PubMed

December 2018. Discovery of common and rare genetic risk variants for colorectal cancer. Huyghe JR, Bien SA, Harrison TA, Kang HM, Chen S, Schmit SL, Conti DV, Qu C, Jeon J, Edlund CK, Greenside P, Wainberg M, Schumacher FR, Smith JD, Levine DM, Nelson SC, Sinnott-Armstrong NA, Albanes D, Alonso MH, Anderson K, Arnau-Collell C, Arndt V, Bamia C, Banbury BL, Baron JA, Berndt SI, Bézieau S, Bishop DT, Boehm J, Boeing H, Brenner H, Brezina S, Buch S, Buchanan DD, Burnett-Hartman A, Butterbach K, Caan BJ, Campbell PT, Carlson CS, Castellví-Bel S, Chan AT, Chang-Claude J, Chanock SJ, Chirlaque MD, Cho SH, Connolly CM, Cross AJ, Cuk K, Curtis KR, de la Chapelle A, Doheny KF, Duggan D, Easton DF, Elias SG, Elliott F, English DR, Feskens EJM, Figueiredo JC, Fischer R, FitzGerald LM, Forman D, Gala M, Gallinger S, Gauderman WJ, Giles GG, Gillanders E, Gong J, Goodman PJ, Grady WM, et al. Nat Genet. 2018 Dec 3. doi: 10.1038/s41588-018-0286-6. [Epub ahead of print]

November 2018. Epigenetic Heterogeneity in Human Colorectal Tumors Reveals Preferential Conservation And Evidence of Immune Surveillance. Ryser MD, Yu M, Grady W, Siegmund K, Shibata D. Sci Rep. 2018 Nov 23;8(1):17292. doi: 10.1038/s41598-018-35621-y.

November 2018. Mendelian randomization analysis of C-reactive protein on colorectal cancer risk. Wang X, Dai JY, Albanes D, Arndt V, Berndt SI, Bézieau S, Brenner H, Buchanan DD, Butterbach K, Caan B, Casey G, Campbell PT, Chan AT, Chen Z, Chang-Claude J, Cotterchio M, Easton DF, Giles GG, Giovannucci E, Grady WM, Hoffmeister M, Hopper JL, Hsu L, Jenkins MA, Joshi AD, Lampe JW, Larsson SC, Lejbkowicz F, Li L, Lindblom A, Le Marchand L, Martin V, Milne RL, Moreno V, Newcomb PA, Offitt K, Ogino S, Pharoah PDP, Pinchev M, Potter JD, Rennert HS, Rennert G, Saliba W, Schafmayer C, Schoen RE, Schrotz-King P, Slattery ML, Song M, Stegmaier C, Weinstein SJ, Wolk A, Woods MO, Wu AH, Gruber SB, Peters U, White E. Int J Epidemiol. 2018 Nov 21. doi: 10.1093/ije/dyy244. [Epub ahead of print]

October 2018. Implications of epigenetic drift in colorectal neoplasia. Luebeck GE, Hazelton WD, Curtius K, Maden SK, Yu M, Carter KT, Burke W, Lampe PD, Li CI, Ulrich CM, Newcomb PA, Westerhoff M, Kaz AM, Luo Y, Inadomi JM, Grady WM. Cancer Res. 2018 Oct 5. pii: canres.1682.2018. doi: 10.1158/0008-5472.CAN-18-1682. [Epub ahead of print]

September 2018. Rare loss of function variants in candidate genes and risk of colorectal cancer. Rosenthal EA, Shirts BH, Amendola LM, Horike-Pyne M, Robertson PD, Hisama FM, Bennett RL, Dorschner MO, Nickerson DA, Stanaway IB, Nassir R, Vickers KT, Li C, Grady WM, Peters U, Jarvik GP; NHLBI GO Exome Sequencing Project. Hum Genet. 2018 Sep 28. doi: 10.1007/s00439-018-1938-4. [Epub ahead of print]

August 2018. NCCN Guidelines Insights: Colorectal Cancer Screening, Version 1.2018. Provenzale D, Gupta S, Ahnen DJ, Markowitz AJ, Chung DC, Mayer RJ, Regenbogen SE, Blanco AM, Bray T, Cooper G, Early DS, Ford JM, Giardiello FM, Grady W, Hall MJ, Halverson AL, Hamilton SR, Hampel H, Klapman JB, Larson DW, Lazenby AJ, Llor X, Lynch PM, Mikkelson J, Ness RM, Slavin TP Jr, Sugandha S, Weiss JM, Dwyer MA, Ogba N. J Natl Compr Canc Netw. 2018 Aug;16(8):939-949. doi: 10.6004/jnccn.2018.0067.

June 2018. Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis. Poudel KR, Roh-Johnson M, Su A, Ho T, Mathsyaraja H, Anderson S, Grady WM, Moens CB, Conacci-Sorrell M, Eisenman RN, Bai J. Dev Cell. 2018 Jun 18;45(6):738-752.e6. doi: 10.1016/j.devcel.2018.05.021.

June 2018. Novel Common Genetic Susceptibility Loci for Colorectal Cancer. Schmit SL, Edlund CK, Schumacher FR, Gong J, Harrison TA, Huyghe JR, Qu C, Melas M, Van Den Berg DJ, Wang H, Tring S, Plummer SJ, Albanes D, Alonso MH, Amos CI, Anton K, Aragaki AK, Arndt V, Barry EL, Berndt SI, Bezieau S, Bien S, Bloomer A, Boehm J, Boutron-Ruault MC, Brenner H, Brezina S, Buchanan DD, Butterbach K, Caan BJ, Campbell PT, Carlson CS, Castelao JE, Chan AT, Chang-Claude J, Chanock SJ, Cheng I, Cheng YW, Chin LS, Church JM, Church T, Coetzee GA, Cotterchio M, Cruz Correa M, Curtis KR, Duggan D, Easton DF, English D, Feskens EJM, Fischer R, FitzGerald LM, Fortini BK, Fritsche LG, Fuchs CS, Gago-Dominguez M, Gala M, Gallinger SJ, Gauderman WJ, Giles GG, Giovannucci EL, Gogarten SM, Gonzalez-Villalpando C, Gonzalez-Villalpando EM, Grady WM, et al. J Natl Cancer Inst. 2018 Jun 16. doi: 10.1093/jnci/djy099. [Epub ahead of print]

June 2018. Subtypes of Barrett's oesophagus and oesophageal adenocarcinoma based on genome-wide methylation analysis. Yu M, Maden SK, Stachler M, Kaz AM, Ayers J, Guo Y, Carter KT, Willbanks A, Heinzerling TJ, O'Leary RM, Xu X, Bass A, Chandar AK, Chak A, Elliott R, Willis JE, Markowitz SD, Grady WM. Gut. 2018 Jun 8. pii: gutjnl-2017-314544. doi: 10.1136/gutjnl-2017-314544. [Epub ahead of print]

May 2018. Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer. Neumeyer S, Banbury BL, Arndt V, Berndt SI, Bezieau S, Bien SA, Buchanan DD, Butterbach K, Caan BJ, Campbell PT, Casey G, Chan AT, Chanock SJ, Dai JY, Gallinger S, Giovannucci EL, Giles GG, Grady WM, Hampe J, Hoffmeister M, Hopper JL, Hsu L, Jenkins MA, Joshi A, Larsson SC, Le Marchand L, Lindblom A, Moreno V, Lemire M, Li L, Lin Y, Offit K, Newcomb PA, Pharaoh PD, Potter JD, Qi L, Rennert G, Schafmayer C, Schoen RE, Slattery ML, Song M, Ulrich CM, Win AK, White E, Wolk A, Woods MO, Wu AH, Gruber SB, Brenner H, Peters U, Chang-Claude J. Br J Cancer. 2018 May 24. doi: 10.1038/s41416-018-0108-8. [Epub ahead of print]

May 2018. Molecular Evolution of Metaplasia to Adenocarcinoma in the Esophagus. Grady WM, Yu M. Dig Dis Sci. 2018 May 15. doi: 10.1007/s10620-018-5090-8. [Epub ahead of print]

May 2018. DNA Methylation Analysis Using Droplet Digital PCR. Yu M, Heinzerling TJ, Grady WM. Methods Mol Biol. 2018;1768:363-383. doi: 10.1007/978-1-4939-7778-9_21.

March 2018. Genetic mechanisms of immune evasion in colorectal cancer. Grasso CS, Giannakis M, Wells DK, Hamada T, Mu XJ, Quist M, Nowak JA, Nishihara R, Qian ZR, Inamura K, Morikawa T, Nosho K, Abril-Rodriguez G, Connolly C, Escuin-Ordinas H, Geybels MS, Grady WM, Hsu L, Hu-Lieskovan S, Huyghe JR, Kim YJ, Krystofinski PE, Leiserson MD, Montoya DJ, Nadel BB, Pellegrini M, Pritchard CC, Puig-Saus C, Quist EH, Raphael BJ, Salipante SJ, Shin DS, Shinbrot E, Shirts B, Shukla S, Stanford JL, Sun W, Tsoi J, Upfill-Brown A, Wheeler DA, Wu CJ, Yu M, Zaidi SH, Zaretsky JM, Gabriel SB, Lander ES, Garraway LA, Hudson TJ, Fuchs CS, Ribas A, Ogino S, Peters U. Cancer Discov. 2018 Mar 6. pii: CD-17-1327. doi: 10.1158/2159-8290.CD-17-1327. [Epub ahead of print]

December 2017. NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 3.2017. Gupta S, Provenzale D, Regenbogen SE, Hampel H, Slavin TP Jr, Hall MJ, Llor X, Chung DC, Ahnen DJ, Bray T, Cooper G, Early DS, Ford JM, Giardiello FM, Grady W, Halverson AL, Hamilton SR, Klapman JB, Larson DW, Lazenby AJ, Lynch PM, Markowitz AJ, Mayer RJ, Ness RM, Samadder NJ, Shike M, Sugandha S, Weiss JM, Dwyer MA, Ogba N. J Natl Compr Canc Netw. 2017 Dec;15(12):1465-1475. doi: 10.6004/jnccn.2017.0176.

October 2017. Identification of a key role of widespread epigenetic drift in Barrett's esophagus and esophageal adenocarcinoma. Luebeck EG, Curtius K, Hazelton WD, Maden S, Yu M, Thota PN, Patil DT, Chak A, Willis JE, Grady WM. Clin Epigenetics. 2017 Oct 16;9:113. doi: 10.1186/s13148-017-0409-4. eCollection 2017.

October 2017. Dynamic plasma microRNAs are biomarkers for prognosis and early detection of recurrence in colorectal cancer. Yuan Z, Baker K, Redman MW, Wang L, Adams SV, Yu M, Dickinson B, Makar K, Ulrich N, Böhm J, Wurscher M, Westerhoff M, Medwell S, Moonka R, Sinanan M, Fichera A, Vickers K, Grady WM. Br J Cancer. 2017 Oct 10;117(8):1202-1210. doi: 10.1038/bjc.2017.266. Epub 2017 Aug 15.

October 2017. Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer. Barault L, Amatu A, Siravegna G, Ponzetti A, Moran S, Cassingena A, Mussolin B, Falcomatà C, Binder AM, Cristiano C, Oddo D, Guarrera S, Cancelliere C, Bustreo S, Bencardino K, Maden S, Vanzati A, Zavattari P, Matullo G, Truini M, Grady WM, Racca P, Michels KB, Siena S, Esteller M, Bardelli A, Sartore-Bianchi A, Di Nicolantonio F. Gut. 2017 Oct 5. pii: gutjnl-2016-313372. doi: 10.1136/gutjnl-2016-313372. [Epub ahead of print]

August 2017. New insights into the earliest stages of colorectal tumorigenesis. Sievers CK, Grady WM, Halberg RB, Pickhardt PJ. Expert Rev Gastroenterol Hepatol. 2017 Aug;11(8):723-729. doi: 10.1080/17474124.2017.1330150. Epub 2017 May 26.

May 2017. The CpG island methylator phenotype is concordant between primary colorectal carcinoma and matched distant metastases. Cohen SA, Yu M, Baker K, Redman M, Wu C, Heinzerling TJ, Wirtz RM, Charalambous E, Pentheroudakis G, Kotoula V, Kalogeras KT, Fountzilas G, Grady WM. Clin Epigenetics. 2017 May 2;9:46. doi: 10.1186/s13148-017-0347-1. eCollection 2017.

May 2017. BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis. Parang B, Kaz AM, Barrett CW, Short SP, Ning W, Keating CE, Mittal MK, Naik RD, Washington MK, Revetta FL, Smith JJ, Chen X, Wilson KT, Brand T, Bader DM, Tansey WP, Chen R, Brentnall TA, Grady WM, Williams CS. Gut. 2017 May;66(5):852-862. doi: 10.1136/gutjnl-2015-310255. Epub 2016 Jan 14.

March 2017. Erratum to: Global DNA methylation patterns in Barrett's esophagus, dysplastic Barrett's, and esophageal adenocarcinoma are associated with BMI, gender, and tobacco use. Kaz AM, Wong CJ, Varadan V, Willis JE, Chak A, Grady WM. Clin Epigenetics. 2017 Mar 1;9:23. doi: 10.1186/s13148-017-0324-8.

February 2017. Transposon mutagenesis identifies candidate genes that cooperate with loss of Transforming Growth Factor-beta signaling in mouse intestinal neoplasms. Morris SM, Davison J, Carter KT, O'Leary RM, Trobridge P, Knoblaugh SE, Myeroff LL, Markowitz SD, Brett BT, Scheetz TE, Dupuy AJ, Starr TK, Grady WM. Int J Cancer. 2017 Feb 15;140(4):853-863. doi: 10.1002/ijc.30491. Epub 2016 Nov 7.

February 2017. Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression. Sripathy S, Leko V, Adrianse RL, Loe T, Foss EJ, Dalrymple E, Lao U, Gatbonton-Schwager T, Carter KT, Payer B, Paddison PJ, Grady WM, Lee JT, Bartolomei MS, Bedalov A. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1619-1624. doi: 10.1073/pnas.1621356114. Epub 2017 Jan 31.

November 2016. Use of NCCN Guidelines, Other Guidelines, and Biomarkers for Colorectal Cancer Screening. Williams CD, Grady WM, Zullig LL. J Natl Compr Canc Netw. 2016 Nov;14(11):1479-1485. Review.

October 2016. Global DNA methylation patterns in Barrett's esophagus, dysplastic Barrett's, and esophageal adenocarcinoma are associated with BMI, gender, and tobacco use. Kaz AM, Wong CJ, Varadan V, Willis JE, Chak A, Grady WM. Clin Epigenetics. 2016 Oct 27;8:111.

October 2016. Single cell lineage tracing reveals a role for TgfβR2 in intestinal stem cell dynamics and differentiation. Fischer JM, Calabrese PP, Miller AJ, Muñoz NM, Grady WM, Shibata D, Liskay RM. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12192-12197.

September 2016. WRN promoter CpG island hypermethylation does not predict more favorable outcomes for metastatic colorectal cancer patients treated with irinotecan-based therapy. Bosch LJ, Luo Y, Valinluck Lao V, Snaebjornsson P, Trooskens G, Vlassenbroeck I, Mongera S, Tang W, Welcsh P, Herman JG, Koopman M, Nagtegaal I, Punt CJ, Van Criekinge W, Meijer GA, Monnat RJ, Carvalho B, Grady WM. Clin Cancer Res. 2016 Sep 15;22(18):4612-22. doi: 10.1158/1078-0432.CCR-15-2703. Epub 2016 Apr 27.

September 2016. MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation. Anderson S, Poudel KR, Roh-Johnson M, Brabletz T, Yu M, Borenstein-Auerbach N, Grady WN, Bai J, Moens CB, Eisenman RN, Conacci-Sorrell M. Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5481-90. doi: 10.1073/pnas.1610994113. Epub 2016 Aug 26.

September 2016. Frequent PIK3CA Mutations in Colorectal and Endometrial Tumors with 2 or More Somatic Mutations in Mismatch Repair Genes. Cohen SA, Turner EH, Beightol MB, Jacobson A, Gooley TA, Salipante SJ, Haraldsdottir S, Smith C, Scroggins S, Tait JF, Grady WM, Lin EH, Cohn DE, Goodfellow PJ, Arnold MW, de la Chapelle A, Pearlman R, Hampel H, Pritchard CC. Gastroenterology. 2016 Sep;151(3):440-447.e1. doi: 10.1053/j.gastro.2016.06.004. Epub 2016 Jun 11.

September 2016. Epigenetic silencing of TPM2 contributes to colorectal cancer progression upon RhoA activation. Cui J, Cai Y, Hu Y, Huang Z, Luo Y, Kaz AM, Yang Z, Chen D, Fan X, Grady WM, Wang J. Tumour Biol. 2016 Sep;37(9):12477-12483. Epub 2016 Jun 23.

Contact Info
Education

M.D., University of Michigan Medical School, Ann Arbor, MI

Residency in Medicine,University of Washington, Seattle, WA

Fellowship in Gastroenterology, University of Michigan Medical School, Ann Arbor, MI & Case Western Reserve University, Cleveland, OH

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