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Robert L. Carithers, Jr., MD
Professor
Biography

Dr. Carithers is a UW professor of medicine. He is head of UW Medical Center's liver care services and medical director of the liver transplant program at UWMC. His clinical interests include hepatitis C, hepatitis B, alcoholic liver disease, autoimmune liver disease, primary biliary cirrhosis, Wilson disease, hepatocellular carcinoma and liver transplantation.

Recent Publications
Displaying 20 Most Recent Publications from PubMed

May 2018. Corticosteroids Reduce Risk of Death Within 28 Days for Patients With Severe Alcoholic Hepatitis, Compared With Pentoxifylline or Placebo-a Meta-analysis of Individual Data. Louvet A, Thursz MR, Kim DJ, Labreuche J, Atkinson S, Sidhu SS, O'Grady JG, Akriviadis E, Sinakos E, Carithers RL Jr, Ramond MJ, Maddrey WC, Morgan TR, Duhamel A, Mathurin P. Gastroenterology. 2018 May 5. pii: S0016-5085(18)34495-0. doi: 10.1053/j.gastro.2018.05.011. [Epub ahead of print]

December 2017. Recent trends in liver transplantation for alcoholic liver disease in the United States. Kling CE, Perkins JD, Carithers RL, Donovan DM, Sibulesky L. World J Hepatol. 2017 Dec 28;9(36):1315-1321. doi: 10.4254/wjh.v9.i36.1315.

March 2016. Hepatitis B Virus-Specific and Global T-Cell Dysfunction in Chronic Hepatitis B. Park JJ, Wong DK, Wahed AS, Lee WM, Feld JJ, Terrault N, Khalili M, Sterling RK, Kowdley KV, Bzowej N, Lau DT, Kim WR, Smith C, Carithers RL, Torrey KW, Keith JW, Levine DL, Traum D, Ho S, Valiga ME, Johnson GS, Doo E, Lok AS, Chang KM; HBRN. Gastroenterology. 2016 Mar;150(3):684-695.e5. doi: 10.1053/j.gastro.2015.11.050. Epub 2015 Dec 10.

August 2015. Combining Data from Liver Disease Scoring Systems Better Predicts Outcomes of Patients with Alcoholic Hepatitis. Louvet A, Labreuche J, Artru F, Boursier J, Kim DJ, O'Grady J, Trépo E, Nahon P, Ganne-Carrié N, Naveau S, Carithers RL, Diaz E, Gustot T, Lassailly G, Cannesson-Leroy A, Canva-Delcambre V, Dharancy S, Park SH, Moreno C, Morgan TR, Duhamel A, Mathurin P. Gastroenterology. 2015 Aug;149(2):398-406.e8; quiz e16-7. doi: 10.1053/j.gastro.2015.04.044. Epub 2015 Apr 29.

December 2014. Congestive hepatic fibrosis score: a novel histologic assessment of clinical severity. Dai DF, Swanson PE, Krieger EV, Liou IW, Carithers RL, Yeh MM. Mod Pathol. 2014 Dec;27(12):1552-8. doi: 10.1038/modpathol.2014.79. Epub 2014 Jun 13.

April 2014. Advancing the High Throughput Identification of Disease Specific Protein Signatures Using Multiplexed Ion Mobility Spectrometry. Baker ES, Burnum-Johnson KE, Jacobs JM, Diamond DL, Brown RN, Ibrahim YM, Orton DJ, Piehowski PD, Purdy DE, Moore RJ, Danielson WF 3rd, Monroe ME, Crowell KL, Slysz GW, Gritsenko MA, Sandoval JD, Lamarche BL, Matzke MM, Webb-Robertson BJ, Simmons BC, McMahon BJ, Bhattacharya R, Perkins JD, Carithers RL Jr, Strom S, Self SG, Katze MG, Anderson GA, Smith RD. Mol Cell Proteomics. 2014 Apr;13(4):1119-27. doi: 10.1074/mcp.M113.034595. Epub 2014 Jan 8.

September 2013. The HALOS-ND model: a step in the journey of predicting hospital length of stay after liver transplantation. Krishnan KR, Bhattacharya R, Pereira A, Otto AK, Carithers RL Jr, Reyes JD, Perkins JD. Clin Transplant. 2013 Nov;27(6):809-22. doi: 10.1111/ctr.12217. Epub 2013 Sep 2.

June 2013. Phase I adjuvant trial of sorafenib in patients with hepatocellular carcinoma after orthotopic liver transplantation. Jia N, Liou I, Halldorson J, Carithers R, Perkins J, Reyes J, Yeh M, Stohr E, Rao S, Lin EH. Anticancer Res. 2013 Jun;33(6):2797-800.

September 2012. Clinical factors predicting readmission after orthotopic liver transplantation. Pereira AA, Bhattacharya R, Carithers R, Reyes J, Perkins J. Liver Transpl. 2012 Sep;18(9):1037-45. doi: 10.1002/lt.23475

July 2012. Cardiac disease evaluation and management among kidney and liver transplantation candidates. Lentine KL, Costa SP, Weir MR, Robb JF, Fleisher LA, Kasiske BL, Carithers RL, Ragosta M, Bolton K, Auerbach AD, Eagle KA; American Heart Association Council on the Kidney in Cardiovascular Disease and Council on Peripheral Vascular Disease; American Hear Circulation. 2012 Jul 31;126(5):617-63. Epub 2012 Jul 2.

July 2012. Cardiac disease evaluation and management among kidney and liver transplantation candidates: a scientific statement from the American Heart Association and the American College of Cardiology Foundation Lentine KL, Costa SP, Weir MR, Robb JF, Fleisher LA, Kasiske BL, Carithers RL, Ragosta M, Bolton K, Auerbach AD, Eagle KA; American Heart Association Council on the Kidney in Cardiovascular Disease and Council on Peripheral Vascular Disease. J Am Coll Cardiol. 2012 Jul 31;60(5):434-80. Epub 2012 Jul 2

July 2012. Early transcriptional programming links progression to hepatitis C virus-induced severe liver disease in transplant patients Rasmussen AL, Tchitchek N, Susnow NJ, Krasnoselsky AL, Diamond DL, Yeh MM, Proll SC, Korth MJ, Walters KA, Lederer S, Larson AM, Carithers RL, Benecke A, Katze MG. Hepatology. 2012 Jul;56(1):17-27. doi: 10.1002/hep.25612. Epub 2012 Jun 5

July 2012. Proteome and computational analyses reveal new insights into the mechanisms of hepatitis C virus mediated liver disease post-transplantation. Diamond DL, Krasnoselsky AL, Burnum KE, Monroe ME, Webb-Robertson BJ, McDermott JE, Yeh MM, Dzib JF, Susnow N, Strom S, Proll SC, Belisle SE, Purdy DE, Rasmussen AL, Walters KA, Jacobs JM, Gritsenko MA, Camp DG, Bhattacharya R, Perkins JD, Carithers RL Jr, Liou IW, Larson AM, Benecke A, Waters KM, Smith RD, Katze MG. Hepatology. 2012 Jul;56(1):28-38. doi: 10.1002/hep.25649. Epub 2012 Apr 24.

February 2011. Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: meta-analysis of individual patient data. Mathurin P, O'Grady J, Carithers RL, Phillips M, Louvet A, Mendenhall CL, Ramond MJ, Naveau S, Maddrey WC, Morgan TR. Gut. 2011 Feb;60(2):255-60. Epub 2010 Oct 12.

December 2010. The use of hepatitis B core antibody-positive donor livers does not appear to have a deleterious effect on graft survival in liver transplantation for hepatitis C. Rayhill S, Schwartz J, Ham J, Carithers R, Lei Y, Bhattacharya R, Liou I, Landis C, Lamaye A, Rakita R, Dick A, Healey P, Halldorson J, Bhakthavatsalam R, Perkins J, Reyes J. Transplant Proc. 2010 Dec;42(10):4141-4. doi: 10.1016/j.transproceed.2010.09.023.

July 2010. Genetic diversity of hepatitis C virus predicts recurrent disease after liver transplantation. Li H, Sullivan DG, Feuerborn N, McArdle S, Bekele K, Pal S, Yeh M, Carithers RL, Perkins JD, Gretch DR. Virology. 2010 Jul 5;402(2):248-55. Epub 2010 Apr 18.

July 2010. Use of an automated clinical management system improves outpatient immunosuppressive care following liver transplantation Park ES, Peccoud MR, Wicks KA, Halldorson JB, Carithers RL Jr, Reyes JD, Perkins JD. Park ES, Peccoud MR, Wicks KA, Halldorson JB, Carithers RL Jr, Reyes JD, Perkins JD.

March 2010. Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1. Pal S, Polyak SJ, Bano N, Qiu WC, Carithers RL, Shuhart M, Gretch DR, Das A. J Gastroenterol Hepatol. 2010 Mar;25(3):627-34. Epub 2010 Jan 14.

August 2009. Liver transplantation at the extremes of the body mass index. Dick AA, Spitzer AL, Seifert CF, Deckert A, Carithers RL Jr, Reyes JD, Perkins JD Liver Transpl. 2009 Aug;15(8):968-77

February 2009. Should liver transplantation in patients with model for end-stage liver disease scores < or = 14 be avoided? A decision analysis approach Perkins JD, Halldorson JB, Bakthavatsalam R, Fix OK, Carithers RL Jr, Reyes JD Liver Transpl. 2009 Feb;15(2):242-54.

August 2008. Investigation of putative multisubtype hepatitis C virus infections in vivo by heteroduplex mobility analysis of core/envelope subgenomes. Li H, Thomassen LV, Majid A, McMahon BJ, Bruden D, McArdle S, Bano N, Chung M, Carithers RL, Perkins JD, Sullivan DG, Gretch DR J Virol. 2008 Aug;82(15):7524-32. Epub 2008 May 21

May 2008. Liver transplantation for hepatocellular carcinoma: impact of the MELD allocation system and predictors of survival. Ioannou GN, Perkins JD, Carithers RL Jr Gastroenterology. 2008 May;134(5):1342-51. Epub 2008 Feb 13

March 2008. Clinical trial: interferon alpha-2b continuous long-term therapy vs. repeated 24-week cycles for re-treating chronic hepatitis C. McHutchison JG, Patel K, Schiff ER, Gitlin N, Mur RE, Everson GT, Carithers RL Jr, Davis GL, Marcellin P, Shiffman ML, Harvey J, Albrecht JK International Hepatitis Interventional Therapy Group. Aliment Pharmacol Ther. 2008 Mar 1;27(5):422-32. Epub 2007 Dec 11

September 2007. Proteomic profiling of human liver biopsies: hepatitis C virus-induced fibrosis and mitochondrial dysfunction. Diamond DL, Jacobs JM, Paeper B, Proll SC, Gritsenko MA, Carithers RL Jr, Larson AM, Yeh MM, Camp DG 2nd, Smith RD, Katze MG Hepatology. 2007 Sep;46(3):649-57

April 2007. Recipient and donor factors influence the incidence of graft-vs.-host disease in liver transplant patients Chan EY, Larson AM, Gernsheimer TB, <br>Kowdley KV, Carithers RL, Reyes JD, Perkins JD Liver Transpl. 2007 Apr;13(4):516-22

July 2006. Identification of a specific gene expression pattern associated with HCV-induced pathogenesis in HCV- and HCV/HIV-infected individuals. Walters KA, Smith MW, Pal S, Thompson JC, Thomas MJ, Yeh MM, Thomas DL, Fitzgibbon M, Proll S, Fausto N, Gretch DR, Carithers RL Jr, Shuhart MC, Katze MG. Virology. 2006 Jul 5;350(2):453-64. Epub 2006 Mar 30.

April 2006. Productive replication of hepatitis C virus in perihepatic lymph nodes in vivo: implications of HCV lymphotropism. Pal S, Sullivan DG, Kim S, Lai KK, Kae J, Cotler SJ, Carithers RL Jr, Wood BL, Perkins JD, Gretch DR Gastroenterology. 2006 Apr;130(4):1107-16

January 2006. Gene expression patterns that correlate with hepatitis C and early progression to fibrosis in liver transplant recipients. Smith MW, Walters KA, Korth MJ, Fitzgibbon M, Proll S, Thompson JC, Yeh MM, Shuhart MC, Furlong JC, Cox PP, Thomas DL, Phillips JD, Kushner JP, Fausto N, Carithers RL Jr, Katze MG Gastroenterology. 2006 Jan;130(1):179-87

December 2005. Liver transplantation for erythropoietic protoporphyria liver disease. McGuire BM, Bonkovsky HL, Carithers RL Jr, Chung RT, Goldstein LI, Lake JR, Lok AS, Potter CJ, Rand E, Voigt MD, Davis PR, Bloomer JR. Liver Transpl. 2005 Dec;11(12):1590-6.

November 2005. Methotrexate (MTX) plus ursodeoxycholic acid (UDCA) in the treatment of primary biliary cirrhosis. Combes B, Emerson SS, Flye NL, Munoz SJ, Luketic VA, Mayo MJ, McCashland TM, Zetterman RK, Peters MG, Di Bisceglie AM, Benner KG, Kowdley KV, Carithers RL Jr, Rosoff L Jr, Garcia-Tsao G, Boyer JL, Boyer TD, Martinez EJ, Bass NM, Lake JR, Barnes DS, Bonaci Hepatology. 2005 Nov;42(5):1184-93.

Contact Info
Education

M.D., University of Pennsylvania, Philadelphia, PA

Residency in Medicine, N. Carolina Memorial Hospital, Chapel Hill, NC

Fellowship in Liver Disease, Medical College of Virginia, Richmond, VA

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