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David M. Hockenbery, MD
Professor & Head, Gastroenterology & Hepatology Section, Member, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance
Biography

Members of Dr. Hockenbery's laboratory study the genetic and biochemical mechanisms of programmed cell death, or apoptosis, in a variety of experimental systems. Normal cell death occurring during development and following terminal differentiation has typical morphologic and biochemical features collectively termed apoptosis. The precise control of these events is obviously of great importance to the organism and many model systems have demonstrated the requirement for active RNA and protein synthesis for cell death to proceed, suggesting an internally programmed process. One regulator of this process is the bcl-2 oncogene, which blocks apoptosis in vitro and in vivo and appears to normally control the timing of cell death in many cell lineages.

Recent Publications
Displaying 20 Most Recent Publications from PubMed

August 2018. Analysis of the Myc-induced pancreatic β cell islet tumor microenvironment using imaging ToF-SIMS. Bluestein BM, Morrish F, Graham DJ, Huang L, Hockenbery D, Gamble LJ. Biointerphases. 2018 Aug 28;13(6):06D402. doi: 10.1116/1.5038574.

June 2018. Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation. Centini R, Tsang M, Iwata T, Park H, Delrow J, Margineantu D, Iritani BM, Gu H, Liggitt HD, Kang J, Kang L, Hockenbery DM, Raftery D, Iritani BM. PLoS One. 2018 Jun 13;13(6):e0197973. doi: 10.1371/journal.pone.0197973. eCollection 2018.

May 2018. A Metabolomics Study of BPTES Altered Metabolism in Human Breast Cancer Cell Lines. Nagana Gowda GA, Barding GA Jr, Dai J, Gu H, Margineantu DH, Hockenbery DM, Raftery D. Front Mol Biosci. 2018 May 15;5:49. doi: 10.3389/fmolb.2018.00049. eCollection 2018.

May 2018. Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism. Davis RJ, Gönen M, Margineantu DH, Handeli S, Swanger J, Hoellerbauer P, Paddison PJ, Gu H, Raftery D, Grim JE, Hockenbery DM, Margolin AA, Clurman BE. Proc Natl Acad Sci U S A. 2018 May 7. pii: 201718338. doi: 10.1073/pnas.1718338115. [Epub ahead of print]

April 2018. Inhibition of vaccinia virus replication by nitazoxanide. Hickson SE, Margineantu D, Hockenbery DM, Simon JA, Geballe AP. Virology. 2018 Apr 3;518:398-405. doi: 10.1016/j.virol.2018.03.023. [Epub ahead of print]

March 2018. Pathological assessment of gastrointestinal biopsies from patients with idelalisib-associated diarrhea and colitis. Yeung CC, Hockenbery DM, Westerhoff M, Coutre SE, Sedlak RH, Dubowy RL, Munugalavadla V, Taylor K, Bosch F. Future Oncol. 2018 Mar 23. doi: 10.2217/fon-2017-0528. [Epub ahead of print]

August 2017. Pilot study of lithium to restore intestinal barrier function in severe graft-versus-host disease. Steinbach G, Hockenbery DM, Huls G, Furlong T, Myerson D, Loeb KR, Fann JR, Castilla-Llorente C, McDonald GB, Martin PJ. PLoS One. 2017 Aug 17;12(8):e0183284. doi: 10.1371/journal.pone.0183284. eCollection 2017.

May 2017. Enzyme-Cleavable Polymeric Micelles for the Intracellular De-livery of Pro-Apoptotic Peptides. Kern HB, Srinivasan S, Convertine AJ, Hockenbery D, Press OW, Stayton PS. Mol Pharm. 2017 May 1;14(5):1450-1459. doi: 10.1021/acs.molpharmaceut.6b01178. Epub 2017 Mar 30.

May 2017. Mutant IDH1 regulates the tumor-associated immune system in gliomas. Amankulor NM, Kim Y, Arora S, Kargl J, Szulzewsky F, Hanke M, Margineantu DH, Rao A, Bolouri H, Delrow J, Hockenbery D, Houghton AM, Holland EC. Genes Dev. 2017 Apr 15;31(8):774-786. doi: 10.1101/gad.294991.116. Epub 2017 May 2.

November 2016. Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer. Berger S, Procko E, Margineantu D, Lee EF, Shen BW, Zelter A, Silva DA, Chawla K, Herold MJ, Garnier JM, Johnson R, MacCoss MJ, Lessene G, Davis TN, Stayton PS, Stoddard BL, Fairlie WD, Hockenbery DM, Baker D. Elife. 2016 Nov 2;5. pii: e20352. doi: 10.7554/eLife.20352.

September 2016. Conditional Disruption of Raptor Reveals an Essential Role for mTORC1 in B Cell Development, Survival, and Metabolism. Iwata TN, Ramírez JA, Tsang M, Park H, Margineantu DH, Hockenbery DM, Iritani BM. J Immunol. 2016 Sep 15;197(6):2250-60. doi: 10.4049/jimmunol.1600492. Epub 2016 Aug 12.

September 2016. Response of Steroid-Refractory Acute GVHD to α1-Anti-Trypsin. Marcondes AM, Hockenbery D, Lesnikova M, Dinarello CA, Woolfrey A, Gernsheimer T, Loghman-Adham M, Gelmont D, Storer B, Hansen JA, Deeg HJ. Biol Blood Marrow Transplant. 2016 Sep;22(9):1596-601. doi: 10.1016/j.bbmt.2016.05.011. Epub 2016 May 17.

June 2016. Mitochondrial functions in stem cells. Margineantu DH, Hockenbery DM. Curr Opin Genet Dev. 2016 Jun;38:110-117. doi: 10.1016/j.gde.2016.05.004. Epub 2016 Jun 5.

May 2016. Metabolic Reprogramming and Dependencies Associated with Epithelial Cancer Stem Cells Independent of the Epithelial-Mesenchymal Transition Program. Aguilar E, Marin de Mas I, Zodda E, Marin S, Morrish F, Selivanov V, Meca-Cortés Ó, Delowar H, Pons M, Izquierdo I, Celià-Terrassa T, de Atauri P, Centelles JJ, Hockenbery D, Thomson TM, Cascante M. Stem Cells. 2016 May;34(5):1163-76. doi: 10.1002/stem.2286. Epub 2016 Feb 2.

March 2016. An unsupervised MVA method to compare specific regions in human breast tumor tissue samples using ToF-SIMS. Bluestein BM, Morrish F, Graham DJ, Guenthoer J, Hockenbery D, Porter PL, Gamble LJ. Analyst. 2016 Mar 7;141(6):1947-57. doi: 10.1039/c5an02406d.

December 2015. The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition. Sperber H, Mathieu J, Wang Y, Ferreccio A, Hesson J, Xu Z, Fischer KA, Devi A, Detraux D, Gu H, Battle SL, Showalter M, Valensisi C, Bielas JH, Ericson NG, Margaretha L, Robitaille AM, Margineantu D, Fiehn O, Hockenbery D, Blau CA, Raftery D, Margolin AA, Hawkins RD, Moon RT, Ware CB, Ruohola-Baker H. Nat Cell Biol. 2015 Dec;17(12):1523-35. doi: 10.1038/ncb3264. Epub 2015 Nov 16.

June 2015. Lipid analysis of eight human breast cancer cell lines with ToF-SIMS. Robinson MA, Graham DJ, Morrish F, Hockenbery D, Gamble LJ. Biointerphases. 2015 Jun 28;11(2):02A303. doi: 10.1116/1.4929633.

March 2015. An intracellular delivery system for antibody-peptide drug conjugates. Berguig GY, Convertine AJ, Frayo S, Kern HB, Procko E, Roy D, Srinivasan S, Margineantu DH, Booth G, Palanca-Wessels MC, Baker D, Hockenbery D, Press OW, Stayton PS. Mol Ther. 2015 May;23(5):907-17. doi: 10.1038/mt.2015.22. Epub 2015 Feb 11.

March 2015. ToF-SIMS of tissues: "Lessons learned" from mice and women. Gamble LJ, Graham DJ, Bluestein B, Whitehead NP, Hockenbery D, Morrish F, Porter P. Biointerphases. 2015 Mar 13;10(1):019008. doi: 10.1116/1.4907860.

February 2015. Fibrosing Cholestatic Hepatitis C After Hematopoietic Cell Transplantation: Report of 3 Fatal Cases. Evans AT, Loeb KR, Shulman HM, Hassan S, Qiu WC, Hockenbery DM, Ioannou GN, Chauncey TR, Gretch DR, McDonald GB. Am J Surg Pathol. 2015 Feb;39(2):212-20. doi: 10.1097/PAS.0000000000000345.

January 2015. Fnip1 regulates skeletal muscle fiber type specification, fatigue resistance, and susceptibility to muscular dystrophy. Reyes NL, Banks GB, Tsang M, Margineantu D, Gu H, Djukovic D, Chan J, Torres M, Liggitt HD, Hirenallur-S DK, Hockenbery DM, Raftery D, Iritani BM. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):424-9. doi: 10.1073/pnas.1413021112. Epub 2014 Dec 29.

October 2014. α-1-antitrypsin (AAT)-modified donor cells suppress GVHD but enhance the GVL effect: a role for mitochondrial bioenergetics. Marcondes AM, Karoopongse E, Lesnikova M, Margineantu D, Welte T, Dinarello CA, Hockenbery D, Janciauskiene S, Deeg HJ. Blood. 2014 Oct 30;124(18):2881-91. doi: 10.1182/blood-2014-04-570440. Epub 2014 Sep 15.

June 2014. A computationally designed inhibitor of an epstein-barr viral bcl-2 protein induces apoptosis in infected cells. Procko E, Berguig GY, Shen BW, Song Y, Frayo S, Convertine AJ, Margineantu D, Booth G, Correia BE, Cheng Y, Schief WR, Hockenbery DM, Press OW, Stoddard BL, Stayton PS, Baker D. Cell. 2014 Jun 19;157(7):1644-56. doi: 10.1016/j.cell.2014.04.034.

May 2014. MYC and Mitochondrial Biogenesis. Morrish F, Hockenbery D. Cold Spring Harb Perspect Med. 2014 May 1;4(5). pii: a014225. doi: 10.1101/cshperspect.a014225.

March 2014. Forecast: rough seas for leukemia. Hockenbery DM. Cancer Discov. 2014 Mar;4(3):278-9. doi: 10.1158/2159-8290.CD-14-0084.

February 2013. Warburg and Crabtree Effects in Premalignant Barrett's Esophagus Cell Lines with Active Mitochondria. Suchorolski MT, Paulson TG, Sanchez CA, Hockenbery D, Reid BJ. PLoS One. 2013;8(2):e56884. doi: 10.1371/journal.pone.0056884. Epub 2013 Feb 27.

May 2012. Disruption of Fnip1 reveals a metabolic checkpoint controlling B lymphocyte development. Park H, Staehling K, Tsang M, Appleby MW, Brunkow ME, Margineantu D, Hockenbery DM, Habib T, Liggitt HD, Carlson G, Iritani BM. Immunity. 2012 May 25;36(5):769-81. doi: 10.1016/j.immuni.2012.02.019. Epub 2012 May 17.

March 2012. HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition. Zhou W, Choi M, Margineantu D, Margaretha L, Hesson J, Cavanaugh C, Blau CA, Horwitz MS, Hockenbery D, Ware C, Ruohola-Baker H. EMBO J. 2012 Mar 23;31(9):2103-16. doi: 10.1038/emboj.2012.71.

May 2011. Reduced cytochrome C is an essential regulator of sustained insulin secretion by pancreatic islets. Jung SR, Kuok IT, Couron D, Rizzo N, Margineantu DH, Hockenbery DM, Kim F, Sweet IR J Biol Chem. 2011 May 20;286(20):17422-34. Epub 2011 Mar 10.

April 2011. Blood and Gastric FOXP3+ T Cells Are Not Decreased in Human Gastric Graft Versus Host Disease. Lord JD, Hackman RC, Gooley TA, Wood BL, Moklebust AC, Hockenbery DM, Steinbach G, Ziegler SF, McDonald GB. Biol Blood Marrow Transplant. 2011 Apr;17(4):486-96. Epub 2010 Sep 24.

Contact Info
Education

M.D., Washington University, St. Louis, MO

Residency in Medicine, Johns Hopkins, Baltimore, MD

Fellowship in Gastroenterology, Washington University, St. Louis, MO

Fellowship in Molecular Oncology, Washington University, St. Louis, MO

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