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George B. McDonald, MD
Professor Emeritus & Member, Clinical Research Division,
Gastroenterology & Hepatology Section,
Fred Hutchinson Cancer Research Center
Biography

Dr. McDonald is a professor of medicine in the Division of Gastroenterology and a member in the Clinical Research Division at the Fred Hutchinson Cancer Research Center. His research is in the field of hematopoietic cell transplantation, its outcomes and gastrointestinal, hepatobiliary and renal complications. He is the principal investigator on a study of allogeneic transplantation as a potential cure for severe Crohn's Disease (www.CATS-FHCRC.org).

Recent Publications
Displaying 20 Most Recent Publications from PubMed

August 2018. Liver complications following treatment of hematologic malignancy with anti-cd22-calicheamicin (Inotuzumab Ozogamicin). McDonald GB, Freston JW, Boyer JL, DeLeve LD. Hepatology. 2018 Aug 18. doi: 10.1002/hep.30222. [Epub ahead of print]

June 2018. Hepatic veno-occlusive disease following sirolimus-based immune suppression. Khimani F, McDonald GB, Shulman HM, Betts B, Locke F, Fernandez H, Anasetti C, Pidala J. Bone Marrow Transplant. 2018 Jun 12. doi: 10.1038/s41409-018-0233-2. [Epub ahead of print]

April 2018. Changes in Glomerular Filtration Rate and Impact on Long-Term Survival among Adults after Hematopoietic Cell Transplantation: A Prospective Cohort Study. Hingorani S, Pao E, Stevenson P, Schoch G, Laskin BL, Gooley T, McDonald GB. Clin J Am Soc Nephrol. 2018 Apr 18. pii: CJN.10630917. doi: 10.2215/CJN.10630917. [Epub ahead of print]

August 2017. Pilot study of lithium to restore intestinal barrier function in severe graft-versus-host disease. Steinbach G, Hockenbery DM, Huls G, Furlong T, Myerson D, Loeb KR, Fann JR, Castilla-Llorente C, McDonald GB, Martin PJ. PLoS One. 2017 Aug 17;12(8):e0183284. doi: 10.1371/journal.pone.0183284. eCollection 2017.

August 2017. Predictive Value of Clinical Findings and Plasma Biomarkers after 14 Days of Prednisone Treatment for Acute Graft-Versus-Host Disease. McDonald GB, Tabellini L, Storer BE, Martin PJ, Lawler RL, Rosinski SL, Schoch HG, Hansen JA. Biol Blood Marrow Transplant. 2017 Aug;23(8):1257-1263. doi: 10.1016/j.bbmt.2017.04.029. Epub 2017 May 3.

April 2017. Sinusoidal obstruction syndrome following CD33-targeted therapy in acute myeloid leukemia. Godwin CD, McDonald GB, Walter RB. Blood. 2017 Apr 20;129(16):2330-2332. doi: 10.1182/blood-2017-01-762419. Epub 2017 Feb 2.

December 2016. Decline in the Use of Surgical Biopsy for Diagnosis of Pulmonary Disease in Hematopoietic Cell Transplant Recipients in an Era of Improved Diagnostics and Empirical Therapy. Cheng GS, Stednick Z, Madtes DK, Boeckh M, McDonald GB, Pergam SA. Biol Blood Marrow Transplant. 2016 Dec;22(12):2243-2249. doi: 10.1016/j.bbmt.2016.08.023. Epub 2016 Aug 31.

September 2016. How we treat hepatitis C virus infection in patients with hematologic malignancies. Torres HA, McDonald GB. Blood. 2016 Sep 15;128(11):1449-57. doi: 10.1182/blood-2016-05-718643. Epub 2016 Jul 21.

March 2016. How I treat acute graft-versus-host disease of the gastrointestinal tract and the liver. McDonald GB. Blood. 2016 Mar 24;127(12):1544-50. doi: 10.1182/blood-2015-10-612747. Epub 2016 Jan 4.

December 2015. Subacute hepatic necrosis mimicking veno-occlusive disease in a patient with HFE H63D homozygosity after allogeneic hematopoietic cell transplantation with busulfan conditioning. Chen S, Osborn JD, Chen X, Boyer MW, McDonald GB, Hildebrandt GC. Int J Hematol. 2015 Dec;102(6):729-31.

November 2015. Hepatitis C Virus Infection among Hematopoietic Cell Transplant Donors and Recipients: American Society for Blood and Marrow Transplantation Task Force Recommendations. Torres HA, Chong PP, De Lima M, Friedman MS, Giralt S, Hammond SP, Kiel PJ, Masur H, McDonald GB, Wingard JR, Gambarin-Gelwan M. Biol Blood Marrow Transplant. 2015 Nov;21(11):1870-82. doi: 10.1016/j.bbmt.2015.07.033. Epub 2015 Aug 6.

July 2015. Plasma biomarkers of acute GVHD and non-relapse mortality: predictive value of measurements before GVHD onset and treatment. McDonald GB, Tabellini L, Storer BE, Lawler RL, Martin PJ, Hansen JA. Blood. 2015 Jul 2;126(1):113-20. doi: 10.1182/blood-2015-03-636753. Epub 2015 May 18.

June 2015. Effectiveness and safety of lower-dose prednisone for initial treatment of acute graft-versus-host disease: a randomized controlled trial. Mielcarek M, Furlong T, Storer BE, Green ML, McDonald GB, Carpenter PA, Flowers ME, Storb R, Boeckh M, Martin PJ. Haematologica. 2015 Jun;100(6):842-8. doi: 10.3324/haematol.2014.118471. Epub 2015 Feb 14.

March 2015. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group Report. Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, Palmer J, Weisdorf D, Treister NS, Cheng G, Kerr H, Stratton P, Duarte RF, McDonald GB, Inamoto Y, Vigorito A, Arai S, Datiles MB, Jacobsohn D, Heller T, Kitko CL, Mitchell SA, Martin PJ, Shulman H, Wu RS, Cutler CS, Vogelsang GB, Lee SJ, Pavletic SZ, Flowers ME. Biol Blood Marrow Transplant. 2015 Mar;21(3):389-401.e1. doi: 10.1016/j.bbmt.2014.12.001. Epub 2014 Dec 18.

February 2015. Fibrosing Cholestatic Hepatitis C After Hematopoietic Cell Transplantation: Report of 3 Fatal Cases. Evans AT, Loeb KR, Shulman HM, Hassan S, Qiu WC, Hockenbery DM, Ioannou GN, Chauncey TR, Gretch DR, McDonald GB. Am J Surg Pathol. 2015 Feb;39(2):212-20. doi: 10.1097/PAS.0000000000000345.

January 2015. Urinary Elafin and Kidney Injury in Hematopoietic Cell Transplant Recipients. Hingorani S, Finn LS, Pao E, Lawler R, Schoch G, McDonald GB, Najafian B, Sandmaier B, Gooley T. Clin J Am Soc Nephrol. 2015 Jan 7;10(1):12-20. doi: 10.2215/CJN.01840214. Epub 2014 Nov 11.

August 2014. Gallstones in Pediatric Hematopoietic Cell Transplant Survivors With up to 40 Years of Follow-up. Hoffmeister PA, Storer BE, McDonald GB, Baker KS. J Pediatr Hematol Oncol. 2014 Aug;36(6):484-90. doi: 10.1097/MPH.0000000000000213.

July 2014. Late onset colitis after cord blood transplant is consistent with Graft-Versus-Host Disease: Results of a blinded histopathological review. Milano F, Shulman HM, Guthrie KA, Riffkin I, McDonald GB, Delaney C. Biol Blood Marrow Transplant. 2014 Jul;20(7):1008-13. doi: 10.1016/j.bbmt.2014.03.020. Epub 2014 Apr 3.

September 2013. A novel soluble form of Tim-3 associated with Severe Graft-versus-Host Disease. Hansen JA, Hanash SM, Tabellini L, Baik C, Lawler RL, Grogan BM, Storer BE, Chin A, Johnson M, Wong CH, Zhang Q, Martin PJ, McDonald GB. Biol Blood Marrow Transplant. 2013 Sep;19(9):1323-30. doi: 10.1016/j.bbmt.2013.06.011. Epub 2013 Jun 17.

July 2013. Cyclophosphamide Followed by Intravenous Targeted Busulfan for Allogeneic Hematopoietic Cell Transplantation: Pharmacokinetics and Clinical Outcomes. Rezvani AR, McCune JS, Storer BE, Batchelder A, Kida A, Deeg HJ, McDonald GB. Biol Blood Marrow Transplant. 2013 Jul;19(7):1033-9. doi: 10.1016/j.bbmt.2013.04.005. Epub 2013 Apr 10.

March 2013. Incidence of sinusoidal obstruction syndrome following Mylotarg (gemtuzumab ozogamicin): a prospective observational study of 482 patients in routine clinical practice. Tallman MS, McDonald GB, Deleve LD, Baer MR, Cook MN, Graepel GJ, Kollmer C. Int J Hematol. 2013 Apr;97(4):456-64. doi: 10.1007/s12185-013-1275-2. Epub 2013 Mar 5.

March 2012. National Cancer Institute, National Heart, Lung and Blood Institute/Pediatric Blood and Marrow Transplantation Consortium First International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation: The Need for Pediatric-S Pulsipher MA, Skinner R, McDonald GB, Hingorani S, Armenian SH, Cooke KR, Gracia C, Petryk A, Bhatia S, Bunin N, Nieder ML, Dvorak CC, Sung L, Sanders JE, Kurtzberg J, Scott Baker K. Biol Blood Marrow Transplant. 2012 Mar;18(3):334-47. Epub 2012 Jan 14.

February 2012. Accurate Targeting of Daily Intravenous Busulfan with 8-Hour Blood Sampling in Hospitalized Adult Hematopoietic Cell Transplant Recipients. Yeh RF, Pawlikowski MA, Blough DK, McDonald GB, O'Donnell PV, Rezvani A, Deeg HJ, McCune JS. Biol Blood Marrow Transplant. 2012 Feb;18(2):265-72. Epub 2011 Jul 4.

January 2012. Gastrointestinal, hepatobiliary, pancreatic, and iron-related diseases in long-term survivors of allogeneic hematopoietic cell transplantation. Kida A, McDonald GB. Semin Hematol. 2012 Jan;49(1):43-58.

November 2011. Decreased serum albumin as a biomarker for severe acute graft-versus-host disease after reduced-intensity allogeneic hematopoietic cell transplantation. Rezvani AR, Storer BE, Storb RF, Mielcarek M, Maloney DG, Sandmaier BM, Martin PJ, McDonald GB. Biol Blood Marrow Transplant. 2011 Nov;17(11):1594-601. Epub 2011 Jul 30.

November 2011. National Cancer Institute-National Heart, Lung and Blood Institute/pediatric Blood and Marrow Transplant Consortium First International Consensus Conference on late effects after pediatric hematopoietic cell transplantation: long-term organ damage and dys Nieder ML, McDonald GB, Kida A, Hingorani S, Armenian SH, Cooke KR, Pulsipher MA, Baker KS. Biol Blood Marrow Transplant. 2011 Nov;17(11):1573-84. Epub 2011 Oct 1.

May 2011. A simulation-based comparison of two methods for determining relaxation rates from relaxometry images. Marro K, Otto R, Kolokythas O, Shimamura A, Sanders JE, McDonald GB, Friedman SD. Magn Reson Imaging. 2011 May;29(4):497-506. Epub 2011 Feb 18.

April 2011. Blood and Gastric FOXP3+ T Cells Are Not Decreased in Human Gastric Graft Versus Host Disease. Lord JD, Hackman RC, Gooley TA, Wood BL, Moklebust AC, Hockenbery DM, Steinbach G, Ziegler SF, McDonald GB. Biol Blood Marrow Transplant. 2011 Apr;17(4):486-96. Epub 2010 Sep 24.

April 2011. Cryptosporidium parvum infection vs GVHD after hematopoietic SCT: diagnosis by PCR with resolution of symptoms. Sebastian E, Martin J, McDonald GB, Flores T, Rodriguez A, Blanco A, Vazquez L, de Fuentes I, Cabellero MD Bone Marrow Transplant. 2011 Apr;46(4):612-4. doi: 10.1038/bmt.2010.156. Epub 2010 Jun 28.

December 2010. [Treatment algorithm for gastrointestinal graft-versus-host disease]. McDonald GB. Methods Find Exp Clin Pharmacol. 2010 Dec;32 Suppl A:73-7.

Contact Info
Education

M.D., Washington University, St. Louis, MO

Residency in Medicine, University of Washington, Seattle, WA

Fellowship in Gastroenterology, University of Washington, Seattle, WA

Sabbatical Year of Research, Gastroenterology Unit, Oxford, U.K.

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