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Scott W. Biggins, MD, MAS
Associate Professor & Director, Liver Care Line
Biography

Dr. Scott Biggins is an associate professor of the UW Division of Gastroenterology, director of the Liver Care Line for UW Medicine, chief of Hepatology, and director of the Center for Liver Investigation Fostering Discovery (C-LIFE).

Dr. Biggins is a national recognized clinician, researcher and leader in the field of Hepatology. He received his undergraduate degree in chemical engineering (bioengineering option) from the University of California, Los Angeles (1994) and his medical degree from the University of Southern California (1999). He completed a residency in Internal Medicine at Oregon Health & Science University (2002) and his Gastroenterology fellowship training at the University of California, San Francisco (2005). He was also awarded a Masters degree in Clinical Research from the University of California, San Francisco (2006).

Dr. Biggins' clinical interests are the risk reduction and management of complications of end-stage liver disease, and the clinical evaluation and care of liver transplant candidates and recipients. He has been recognized as a fellow of American Association for the Study of Liver Diseases (FAASLD), American Society of Transplantation (FAST), and American Gastroenterological Association (AGAF).

His research is focused on improving recipient selection for liver transplantation and revising organ allocation algorithms in order to maximize patient outcomes. His specific skill set includes epidemiology and health services research methods. In particular, Dr. Biggins is responsible for revising the original “MELD” score for liver organ allocation to include the serum sodium, which is now the standard of care for liver transplantation in the United States (and internationally). He has received research funding from the American Liver Foundation, National Institutes of Health and the Agency for Healthcare Research and Quality.

He has published over 70 papers in peer-reviewed journals including the New England Journal of Medicine, Gastroenterology, Hepatology, and Liver Transplantation, 8 book chapters, and over 80 published abstracts.

Recent Publications
Displaying 20 Most Recent Publications from PubMed

June 2019. New Evidence Supporting Increased Use of Split Liver Transplantation. Perkins JD, Dick AA, Healey PJ, Montenovo MI, Biggins SW, Sibulesky L, Reyes JD. Transplantation. 2019 Jun 27. doi: 10.1097/TP.0000000000002853. [Epub ahead of print]

June 2019. Copper Deficiency in Liver Diseases: A Case Series and Pathophysiological Considerations. Yu L, Liou IW, Biggins SW, Yeh M, Jalikis F, Chan LN, Burkhead J. Hepatol Commun. 2019 Jun 26;3(8):1159-1165. doi: 10.1002/hep4.1393. eCollection 2019 Aug.

June 2019. Nosocomial Infections Are Frequent and Negatively Impact Outcomes in Hospitalized Patients With Cirrhosis. Bajaj JS, OʼLeary JG, Tandon P, Wong F, Garcia-Tsao G, Kamath PS, Biggins SW, Lai JC, Vargas HE, Maliakkal B, Fallon MB, Thuluvath PJ, Subramanian RM, Thacker LR, Reddy KR. Am J Gastroenterol. 2019 Jun 6. doi: 10.14309/ajg.0000000000000280. [Epub ahead of print]

May 2019. Listing practices and graft utilization of hepatitis C-positive deceased donors in liver and kidney transplant. Kling CE, Perkins JD, Biggins SW, Johnson CK, Limaye AP, Sibulesky L. Surgery. 2019 May 6. pii: S0039-6060(19)30166-7. doi: 10.1016/j.surg.2019.03.015. [Epub ahead of print]

April 2019. Targets to improve quality of care for patients with hepatic encephalopathy: data from a multi-centre cohort. Bajaj JS, O'Leary JG, Tandon P, Wong F, Kamath PS, Biggins SW, Garcia-Tsao G, Lai J, Fallon MB, Thuluvath PJ, Vargas HE, Maliakkal B, Subramanian RM, Thacker LR, Reddy KR. Aliment Pharmacol Ther. 2019 Apr 29. doi: 10.1111/apt.15265. [Epub ahead of print]

April 2019. Albumin in Cirrhosis: More Than a Colloid. Paine CH, Biggins SW, Pichler RH. Curr Treat Options Gastroenterol. 2019 Apr 9. doi: 10.1007/s11938-019-00227-4. [Epub ahead of print]

March 2019. Thromboelastography Parameters Are Associated with Cirrhosis Severity. Kohli R, Shingina A, New S, Chaturvedi S, Benson A, Biggins SW, Bambha K. Dig Dis Sci. 2019 Mar 26. doi: 10.1007/s10620-019-05597-4. [Epub ahead of print]

March 2019. Impact of Chronic Kidney Disease on Outcomes in Cirrhosis. Wong F, Reddy RK, O'Leary JG, Tandon P, Biggins SW, Garcia-Tsao G, Maliakkal BJ, Lai JC, Fallon MB, Vargas HE, Subramanian R, Thuluvath PJ, Kamath PS, Thacker L, Bajaj JS. Liver Transpl. 2019 Mar 25. doi: 10.1002/lt.25454. [Epub ahead of print]

February 2019. Outcomes after Listing for Liver Transplant in Patients with Acute-on-Chronic Liver Failure (ACLF): The Multicenter NACSELD Experience. O'Leary JG, Bajaj JS, Tandon P, Biggins SW, Wong F, Kamath PS, Garcia-Tsao G, Maliakkal B, Lai J, Fallon M, Vargas HE, Thuluvath P, Subramanian R, Thacker LR, Reddy RK. Liver Transpl. 2019 Feb 5. doi: 10.1002/lt.25426. [Epub ahead of print]

February 2019. Reply. Biggins SW, Dodge J, Bambha K. Clin Gastroenterol Hepatol. 2019 Feb;17(3):574-575. doi: 10.1016/j.cgh.2018.08.062.

January 2019. A Simple Measure of Hepatocellular Carcinoma Burden Predicts Tumor Recurrence after Liver Transplantation: The RH-IML Classification. Vutien P, Dodge J, Bambha KM, Nordstrom EM, Gralla J, Campbell K, Levek C, Nydam T, Fix O, Ioannou G, Biggins SW. Liver Transpl. 2019 Jan 31. doi: 10.1002/lt.25422. [Epub ahead of print]

November 2018. Future Trends in Demand for Liver Transplant: Birth-Cohort Effects among Patients with NASH and HCC. Shingina A, DeWitt PE, Dodge JL, Biggins SW, Gralla J, Sprague D, Bambha K. Transplantation. 2018 Nov 16. doi: 10.1097/TP.0000000000002497. [Epub ahead of print]

September 2018. Protecting kidneys in liver transplant patients: A pathway to preventive interventions. Sibulesky L, Biggins SW, Pichler R. World J Hepatol. 2018 Sep 27;10(9):637-638. doi: 10.4254/wjh.v10.i9.637.

June 2018. The Impact of Albumin Use on Resolution of Hyponatremia in Hospitalized Patients With Cirrhosis. Bajaj JS, Tandon P, O'Leary JG, Biggins SW, Wong F, Kamath PS, Garcia-Tsao G, Maliakkal B, Lai JC, Fallon M, Thuluvath P, Vargas HE, Subramanian RM, Thacker LR, Reddy KR. Am J Gastroenterol. 2018 Jun 8. doi: 10.1038/s41395-018-0119-3. [Epub ahead of print]

June 2018. NACSELD Acute-on-Chronic Liver Failure (NACSELD-ACLF) Score Predicts 30-Day Survival in Hospitalized Patients with Cirrhosis. O'Leary JG, Reddy KR, Garcia-Tsao G, Biggins SW, Wong F, Fallon MB, Subramanian RM, Kamath PS, Thuluvath P, Vargas HE, Maliakkal B, Tandon P, Lai J, Thacker LR, Bajaj JS. Hepatology. 2018 Jun;67(6):2367-2374. doi: 10.1002/hep.29773. Epub 2018 Apr 19.

May 2018. Calcineurin Inhibitor and Nonsteroidal Anti-inflammatory Drug Interaction: Implications of Changes in Renal Function Associated With Concurrent Use. Delzer LM, Golightly LK, Kiser TH, Biggins SW, Lewis VJ, Kim II. J Clin Pharmacol. 2018 May 25. doi: 10.1002/jcph.1264. [Epub ahead of print]

May 2018. New paradigms for organ allocation and distribution in liver transplantation. Kalra A, Biggins SW. Curr Opin Gastroenterol. 2018 May;34(3):123-131. doi: 10.1097/MOG.0000000000000434.

May 2018. Assessment of the Spectrum of Hepatic Encephalopathy: A Multi-Center Study. Reuter B, Walter K, Bissonnette J, Leise MD, Lai J, Tandon P, Kamath PS, Biggins SW, Rose CF, Wade JB, Bajaj JS. Liver Transpl. 2018 May;24(5):587-594. doi: 10.1002/lt.25032.

April 2018. Neutrophil to Lymphocyte Ratio Associates Independently With Mortality in Hospitalized Patients with Cirrhosis. Rice J, Dodge JL, Bambha KM, Bajaj JS, Reddy KR, Gralla J, Ganapathy D, Mitrani R, Reuter B, Palecki J, Acharya C, Shaw J, Burton JR, Biggins SW. Clin Gastroenterol Hepatol. 2018 Apr 26. pii: S1542-3565(18)30407-5. doi: 10.1016/j.cgh.2018.04.045. [Epub ahead of print]

April 2018. Prediction of Fungal Infection Development and Their Impact on Survival Using the NACSELD Cohort. Bajaj JS, Rajender Reddy K, Tandon P, Wong F, Kamath PS, Biggins SW, Garcia-Tsao G, Fallon M, Maliakkal B, Lai J, Vargas HE, Subramanian RM, Thuluvath P, Thacker LR, O'Leary JG. Am J Gastroenterol. 2018 Apr;113(4):556-563. doi: 10.1038/ajg.2017.471. Epub 2017 Dec 19.

February 2018. Trends in liver transplantation for Hepatitis C in a country with reduced access to direct-acting antiviral agents. Dirchwolf M, Marciano S, Giunta DH, Posadas-Martínez ML, Biggins SW, Ruf AE. Clin Transplant. 2018 Feb 27. doi: 10.1111/ctr.13230. [Epub ahead of print]

April 2017. Hepatic Encephalopathy Is Associated With Mortality in Patients With Cirrhosis Independent of Other Extrahepatic Organ Failures. Bajaj JS, O'Leary JG, Tandon P, Wong F, Garcia-Tsao G, Kamath PS, Maliakkal B, Biggins SW, Thuluvath PJ, Fallon MB, Subramanian RM, Vargas HE, Lai J, Thacker LR, Reddy KR Clin Gastroenterol Hepatol. 2017 Apr;15(4):565-574.e4. doi: 10.1016/j.cgh.2016.09.157. Epub 2016 Oct 5.

March 2017. Gender-Specific Differences in Baseline, Peak, and Delta Serum Creatinine: The NACSELD Experience. O'Leary JG, Wong F, Reddy KR, Garcia-Tsao G, Kamath PS, Biggins SW, Fallon MB, Subramanian RM, Maliakkal B, Thacker L, Bajaj JS Dig Dis Sci. 2017 Mar;62(3):768-776. doi: 10.1007/s10620-016-4416-7. Epub 2016 Dec 26.

February 2017. Neutrophil-to-lymphocyte ratio correlates with proinflammatory neutrophils and predicts death in low model for end-stage liver disease patients with cirrhosis. Kalra A, Wedd JP, Bambha KM, Gralla J, Golden-Mason L, Collins C, Rosen HR, Biggins SW Liver Transpl. 2017 Feb; 23(2):155-165.

January 2017. A Karnofsky performance status-based score predicts death after hospital discharge in patients with cirrhosis. Tandon P, Reddy KR, O'Leary JG, Garcia-Tsao G, Abraldes JG, Wong F, Biggins SW, Maliakkal B, Fallon MB, Subramanian RM, Thuluvath P, Kamath PS, Thacker LR, Bajaj JS Hepatology. 2017 Jan;65(1):217-224. doi: 10.1002/hep.28900. Epub 2016 Nov 29.

November 2016. Revising metrics for aggressiveness assessment in liver transplantation centers. Ruf AE, Dirchwolf M, Biggins SW, Villamil FG J Hepatol. 2016 Nov;65(5):1066-1067. doi: 10.1016/j.jhep.2016.06.033. Epub 2016 Jul 28.

August 2016. Predicting renal recovery after liver transplant with severe pretransplant subacute kidney injury: The impact of warm ischemia time. Laskey HL, Schomaker N, Hung KW, Asrani SK, Jennings L, Nydam TL, Gralla J, Wiseman A, Rosen HR, Biggins SW Liver Transpl. 2016 Aug;22(8):1085-91. doi: 10.1002/lt.24488. Epub 2016 Jul 12.

July 2016. The 3-month readmission rate remains unacceptably high in a large North American cohort of patients with cirrhosis. Bajaj JS, Reddy KR, Tandon P, Wong F, Kamath PS, Garcia-Tsao G, Maliakkal B, Biggins SW, Thuluvath PJ, Fallon MB, Subramanian RM, Vargas H, Thacker LR, O'Leary JG Hepatology. 2016 Jul;64(1):200-8. doi: 10.1002/hep.28414. Epub 2016 Feb 19.

April 2016. Association Between Plasma Level of Galectin-9 and Survival of Patients With Drug-Induced Acute Liver Failure. Rosen HR, Biggins SW, Niki T, Gralla J, Hillman H, Hirashima M, Schilsky M, Lee WM Clin Gastroenterol Hepatol. 2016 Apr; 14(4):606-612.e3.

April 2016. Changing prioritization for transplantation: MELD-Na, hepatocellular carcinoma exceptions, and more. Kalra A, Wedd JP, Biggins SW Curr Opin Organ Transplant. 2016 Apr; 21(2):120-6.

Contact Info
Education

​Fellow, Gastroenterology, University of California, San Francisco

Resident, Medicine, Oregon Health & Sciences University

Intern, Medicine, Oregon Health & Sciences University

M.A.S., Clinical Research, University of California, San Francisco

M.D., Medicine, University of Southern California

B.Chem.Eng., Chemical Engineering-Bioengineering Option, University of California, Los Angeles

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