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Matthew M. Yeh, MD, PhD
Professor of Pathology & Adjunct Professor of Medicine, Director, Gastrointestinal and Hepatic Pathology Fellowship Program
Biography

​Dr. Yeh specializes in liver, gastrointestinal, and pancreatic pathology. His research interests are in liver tumors, nonalcoholic fatty liver disease, liver transplantation and viral hepatitis. He has authored over 150 peer-reviewed manuscripts and many review articles and book chapters in these fields. Recently he is particularly interested in the investigation of fatty liver contributing to liver cancer. Dr. Yeh serves on the editorial board of several pathology and gastroenterology/hepatology journals. He had served as the President of the Hans Popper Hepatopathology Society and President of the Pacific Northwest Society of Pathology. Besides teaching the medical students, residents and fellows at the University of Washington, he also actively delivers lectures in liver and gastrointestinal diseases at national and international conferences. Dr. Yeh also directs the training of the Gastrointestinal and Hepatic Pathology Fellowship Program.

Recent Publications
Displaying 20 Most Recent Publications from PubMed

April 2018. Association of Gastric Intestinal Metaplasia and East Asian Ethnicity with the Risk of Gastric Adenocarcinoma in a U.S. Population. Choi AY, Strate LL, Fix MC, Schmidt RA, Ende AR, Yeh MM, Inadomi JM, Hwang JH. Gastrointest Endosc. 2018 Apr;87(4):1023-1028. doi: 10.1016/j.gie.2017.11.010. Epub 2017 Nov 16.

January 2018. cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation. Brunt E, Aishima S, Clavien PA, Fowler K, Goodman Z, Gores G, Gouw A, Kagen A, Klimstra D, Komuta M, Kondo F, Miksad R, Nakano M, Nakanuma Y, Ng I, Paradis V, Park YN, Quaglia A, Roncalli M, Roskams T, Sakamoto M, Saxena R, Sempoux C, Sirlin C, Stueck A, Thung S, Tsui WMS, Wang XW, Wee A, Yano H, Yeh M, Zen Y, Zucman-Rossi J, Theise N. Hepatology. 2018 Jan 23. doi: 10.1002/hep.29789. [Epub ahead of print]

January 2018. Molecular testing for the clinical diagnosis of fibrolamellar carcinoma. Graham RP, Yeh MM, Lam-Himlin D, Roberts LR, Terracciano L, Cruise MW, Greipp PT, Zreik RT, Jain D, Zaid N, Salaria SN, Jin L, Wang X, Rustin JG, Kerr SE, Sukov WR, Solomon DA, Kakar S, Waterhouse E, Gill RM, Ferrell L, Alves VA, Nart D, Yilmaz F, Roessler S, Longerich T, Schirmacher P, Torbenson MS. Mod Pathol. 2018 Jan;31(1):141-149. doi: 10.1038/modpathol.2017.103. Epub 2017 Sep 1.

November 2017. Primary sclerosing cholangitis is protective against nonalcoholic fatty liver disease in inflammatory bowel disease. Bosch DE, Yeh MM. Hum Pathol. 2017 Nov;69:55-62. doi: 10.1016/j.humpath.2017.09.008. Epub 2017 Sep 29.

November 2017. Radiologically Undetected Hepatocellular Carcinoma in Patients Undergoing Liver Transplantation: An Immunohistochemical Correlation With LI-RADS Score. Xiong W, Cheeney G, Kim S, Kolesnikova V, Henninger B, Alexander J, Swanson PE, Upton MP, Truong CD, Yeh MM. Am J Surg Pathol. 2017 Nov;41(11):1466-1472. doi: 10.1097/PAS.0000000000000955.

August 2017. Genomic variants link to hepatitis C racial disparities. Yeh MM, Boukhar S, Roberts B, Dasgupta N, Daoud SS. Oncotarget. 2017 Aug 1;8(35):59455-59475. doi: 10.18632/oncotarget.19755. eCollection 2017 Aug 29.

August 2017. Superior Patient and Graft Survival in Adult Liver Transplant with Rabbit Antithymocyte Globulin Induction: Experience with 595 Patients. Montenovo MI, Jalikis FG, Li M, Yeh M, Dick A, Hansen R, Reyes JD. Exp Clin Transplant. 2017 Aug;15(4):425-431. doi: 10.6002/ect.2015.0350. Epub 2016 Jun 15.

August 2017. Hepatic small vessel neoplasm, a rare infiltrative vascular neoplasm of uncertain malignant potential. Gill RM, Buelow B, Mather C, Joseph NM, Alves V, Brunt EM, Liu TC, Makhlouf H, Marginean C, Nalbantoglu I, Sempoux C, Snover DC, Thung SN, Yeh MM, Ferrell LD. Hum Pathol. 2016 Aug;54:143-51. doi: 10.1016/j.humpath.2016.03.018. Epub 2016 Apr 14.

July 2017. TLR9 is upregulated in human and murine NASH: pivotal role for inflammatory recruitment and cell survival. Mridha AR, Haczeyni F, Yeh MM, Haigh WG, Ioannou GN, Barn V, Ajamieh H, Adams L, Hamdorf JM, Teoh NC, Farrell GC. Clin Sci (Lond). 2017 Jul 24;131(16):2145-2159. doi: 10.1042/CS20160838. Print 2017 Aug 15.

June 2017. Cholesterol crystallization within hepatocyte lipid droplets and its role in murine NASH. Ioannou GN, Subramanian S, Chait A, Haigh WG, Yeh MM, Farrell GC, Lee SP, Savard C. J Lipid Res. 2017 Jun;58(6):1067-1079. doi: 10.1194/jlr.M072454. Epub 2017 Apr 12.

June 2017. Aggressive non-alcoholic steatohepatitis following rapid weight loss and/or malnutrition. Tsai JH, Ferrell LD, Tan V, Yeh MM, Sarkar M, Gill RM. Mod Pathol. 2017 Jun;30(6):834-842. doi: 10.1038/modpathol.2017.13. Epub 2017 Mar 3.

May 2017. NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. Mridha AR, Wree A, Robertson AA, Yeh MM, Johnson CD, Van Rooyen DM, Haczeyni F, Teoh NC, Savard C, Ioannou GN, Masters SL, Schroder K, Cooper MA, Feldstein AE, Farrell GC. J Hepatol. 2017 May;66(5):1037-1046. doi: 10.1016/j.jhep.2017.01.022. Epub 2017 Feb 3.

April 2017. Massive Gastric Juvenile Polyposis: A Clinicopathologic Study Using SMAD4 Immunohistochemistry. Lawless ME, Toweill DL, Jewell KD, Jain D, Lamps L, Krasinskas AM, Swanson PE, Upton MP, Yeh MM. Am J Clin Pathol. 2017 Apr 1;147(4):390. doi: 10.1093/ajcp/aqx015.

April 2017. CYP1A2 is a predictor of HCC recurrence in HCV-related chronic liver disease: A retrospective multicentric validation study. Sciarra A, Pintea B, Nahm JH, Donadon M, Morenghi E, Maggioni M, Blanc JF, Torzilli G, Yeh M, Bioulac-Sage P, Park YN, Roncalli M, Di Tommaso L. Dig Liver Dis. 2017 Apr;49(4):434-439. doi: 10.1016/j.dld.2016.12.002. Epub 2016 Dec 16.

February 2017. Steatohepatitis-like Changes in Focal Nodular Hyperplasia, A Finding to Distinguish From Steatohepatitic Variant of Hepatocellular Carcinoma. Deniz K, Moreira RK, Yeh MM, Ferrell LD. Am J Surg Pathol. 2017 Feb;41(2):277-281. doi: 10.1097/PAS.0000000000000781.

January 2017. Obeticholic acid improves adipose morphometry and inflammation and reduces steatosis in dietary but not metabolic obesity in mice. Haczeyni F, Poekes L, Wang H, Mridha AR, Barn V, Geoffrey Haigh W, Ioannou GN, Yeh MM, Leclercq IA, Teoh NC, Farrell GC. Obesity (Silver Spring). 2017 Jan;25(1):155-165. doi: 10.1002/oby.21701. Epub 2016 Nov 2.

January 2017. Differences in hepatic expression of iron, inflammation and stress-related genes in patients with nonalcoholic steatohepatitis. Handa P, Vemulakonda AL, Maliken BD, Morgan-Stevenson V, Nelson JE, Dhillon BK, Hennessey KA, Gupta R, Yeh MM, Kowdley KV. Ann Hepatol. 2017 Jan-Feb 2017;16(1):77-85. doi: 10.5604/16652681.1226818.

August 2016. Glutamine Synthetase Immunoreactivity in Peritumoral Hyperplasia in Liver:  Case Report of a Metastatic Paraganglioma With Focal Nodular Hyperplasia-Like Changes and Review of an Additional 54 Liver Masses. Bryant BH, Zenali MJ, Swanson PE, Upton MP, Yeh MM, Cuevas C, Park JO, Westerhoff M. Am J Clin Pathol. 2016 Aug;146(2):254-61. doi: 10.1093/ajcp/aqw056. Epub 2016 May 31. Review.

June 2016. Hepatic adenomas with synchronous or metachronous fibrolamellar carcinomas: both are characterized by LFABP loss. Graham RP, Terracciano LM, Meves A, Vanderboom PM, Dasari S, Yeh MM, Torbenson MS, Cruise MW. Mod Pathol. 2016 Jun;29(6):607-15. doi: 10.1038/modpathol.2016.59. Epub 2016 Mar 25.

June 2016. Vitamin D Deficiency Is Associated With Increased Risk of Non-alcoholic Steatohepatitis in Adults With Non-alcoholic Fatty Liver Disease: Possible Role for MAPK and NF-κB? Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-Stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV. Am J Gastroenterol. 2016 Jun;111(6):852-63. doi: 10.1038/ajg.2016.51. Epub 2016 Mar 22.

August 2015. Irreversible Electroporation Can Effectively Ablate Hepatocellular Carcinoma to Complete Pathologic Necrosis. Cheng RG, Bhattacharya R, Yeh MM, Padia SA. J Vasc Interv Radiol. 2015 Aug;26(8):1184-8. doi: 10.1016/j.jvir.2015.05.014. Epub 2015 Jun 26.

July 2015. Fulminant hepatitis B reactivation leading to liver transplantation in a patient with chronic hepatitis C treated with simeprevir and sofosbuvir: a case report. Ende AR, Kim NH, Yeh MM, Harper J, Landis CS. J Med Case Rep. 2015 Jul 28;9:164. doi: 10.1186/s13256-015-0630-8.

June 2015. Multidisciplinary perspective of hepatocellular carcinoma: A Pacific Northwest experience. Yeh MM, Yeung RS, Apisarnthanarax S, Bhattacharya R, Cuevas C, Harris WP, Hon TL, Padia SA, Park JO, Riggle KM, Daoud SS. World J Hepatol. 2015 Jun 18;7(11):1460-83. doi: 10.4254/wjh.v7.i11.1460. Review.

June 2015. TGF-β signaling alters the pattern of liver tumorigenesis induced by Pten inactivation. Morris SM, Carter KT, Baek JY, Koszarek A, Yeh MM, Knoblaugh SE, Grady WM. Oncogene. 2015 Jun;34(25):3273-82. doi: 10.1038/onc.2014.258. Epub 2014 Aug 18.

February 2015. Cholesterol-lowering drugs cause dissolution of cholesterol crystals and disperse Kupffer cell crown-like structures during resolution of NASH. Ioannou GN, Van Rooyen DM, Savard C, Haigh WG, Yeh MM, Teoh NC, Farrell GC. J Lipid Res. 2015 Feb;56(2):277-85. doi: 10.1194/jlr.M053785. Epub 2014 Dec 17.

December 2014. Congestive hepatic fibrosis score: a novel histologic assessment of clinical severity. Dai DF, Swanson PE, Krieger EV, Liou IW, Carithers RL, Yeh MM. Mod Pathol. 2014 Dec;27(12):1552-8. doi: 10.1038/modpathol.2014.79. Epub 2014 Jun 13.

July 2013. Pharmacological cholesterol lowering reverses fibrotic NASH in obese, diabetic mice with metabolic syndrome. Van Rooyen DM, Gan LT, Yeh MM, Geoffrey Haigh W, Larter CZ, Ioannou G, Teoh NC, Farrell GC. J Hepatol. 2013 Jul;59(1):144-52. doi: 10.1016/j.jhep.2013.02.024. Epub 2013 Mar 7.

June 2013. Phase I adjuvant trial of sorafenib in patients with hepatocellular carcinoma after orthotopic liver transplantation. Jia N, Liou I, Halldorson J, Carithers R, Perkins J, Reyes J, Yeh M, Stohr E, Rao S, Lin EH. Anticancer Res. 2013 Jun;33(6):2797-800.

January 2013. Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis. Savard C, Tartaglione EV, Kuver R, Haigh WG, Farrell GC, Subramanian S, Chait A, Yeh MM, Quinn LS, Ioannou GN. Hepatology. 2013 Jan;57(1):81-92. doi: 10.1002/hep.25789.

July 2012. Early transcriptional programming links progression to hepatitis C virus-induced severe liver disease in transplant patients Rasmussen AL, Tchitchek N, Susnow NJ, Krasnoselsky AL, Diamond DL, Yeh MM, Proll SC, Korth MJ, Walters KA, Lederer S, Larson AM, Carithers RL, Benecke A, Katze MG. Hepatology. 2012 Jul;56(1):17-27. doi: 10.1002/hep.25612. Epub 2012 Jun 5

Contact Info
Education

M.D., National Taiwan University School of Medicine, Taipei

Ph.D., University of Pennsylvania, Philadelphia

Residency in Pathology, George Washington University, DC

Fellowship in Gastrointestinal/Hepatic Pathology, Yale University, New Haven

Board Certified, American Board of Pathology (Anatomic and Clinical Pathology)

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