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Teresa A. Brentnall, MD
Professor
Biography
Dr. Brentnall is a clinical gastroenterologist who also is a cancer researcher. In the clinical realm, she specializes in caring for patients that have an elevated risk of intestinal cancer due to hereditary susceptibility. This includes hereditary colon cancer, pancreatic cancer, stomach cancer to name a few. She is the co-director of the Pancreatic Cancer Surveillance program at the UWMC, along with Dr. Michael Saunders. This is an endoscopic surveillance program for patients who have multiple family members with pancreatic cancer or for patients who have a known gene mutation that predisposes them to pancreatic cancer.
 
On the research side, Dr. Brentnall is working on the earlier detection of pancreatic cancer and IBD-related colon cancer through the development of cancer biomarkers and molecular imaging.
 
Recent Publications
Displaying 20 Most Recent Publications from PubMed

May 2018. Similarities and Differences of Blood N-Glycoproteins in Five Solid Carcinomas at Localized Clinical Stage Analyzed by SWATH-MS. Sajic T, Liu Y, Arvaniti E, Surinova S, Williams EG, Schiess R, Hüttenhain R, Sethi A, Pan S, Brentnall TA, Chen R, Blattmann P, Friedrich B, Niméus E, Malander S, Omlin A, Gillessen S, Claassen M, Aebersold R. Cell Rep. 2018 May 29;23(9):2819-2831.e5. doi: 10.1016/j.celrep.2018.04.114.

January 2018. Precancer in Ulcerative Colitis: The Role of the Field Effect and its Clinical Implications. Baker KT, Salk JJ, Brentnall TA, Risques RA. Carcinogenesis. 2018 Jan 12;39(1):11-20. doi: 10.1093/carcin/bgx117.

September 2017. Spectral library-based glycopeptide analysis - detection of circulating galectin-3 binding protein in pancreatic cancer. Nigjeh EN, Chen R, Allen-Tamura Y, Brand RE, Brentnall TA, Pan S. Proteomics Clin Appl. 2017 Sep;11(9-10). doi: 10.1002/prca.201700064. Epub 2017 Jul 10.

August 2017. Disrupting glutamine metabolic pathways to sensitize gemcitabine-resistant pancreatic cancer. Chen R, Lai LA, Sullivan Y, Wong M, Wang L, Riddell J, Jung L, Pillarisetty VG, Brentnall TA, Pan S. Sci Rep. 2017 Aug 11;7(1):7950. doi: 10.1038/s41598-017-08436-6.

May 2017. BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis. Parang B, Kaz AM, Barrett CW, Short SP, Ning W, Keating CE, Mittal MK, Naik RD, Washington MK, Revetta FL, Smith JJ, Chen X, Wilson KT, Brand T, Bader DM, Tansey WP, Chen R, Brentnall TA, Grady WM, Williams CS. Gut. 2017 May;66(5):852-862. doi: 10.1136/gutjnl-2015-310255. Epub 2016 Jan 14.

February 2017. Quantitative Proteomics Based on Optimized Data-independent-acquisition in Plasma Analysis. N Nigjeh E, Chen R, Brand RE, Petersen GM, Chari ST, von Haller PD, Eng JK, Feng Z, Yan Q, Brentnall TA, Pan S. J Proteome Res. 2017 Feb 3;16(2):665-676. doi: 10.1021/acs.jproteome.6b00727. Epub 2017 Jan 3.

February 2017. Imaging in pancreatic disease. Dimastromatteo J, Brentnall T, Kelly KA. Nat Rev Gastroenterol Hepatol. 2017 Feb;14(2):97-109. doi: 10.1038/nrgastro.2016.144. Epub 2016 Nov 9.

November 2016. Glycoproteins and glycoproteomics in pancreatic cancer. Pan S, Brentnall TA, Chen R. World J Gastroenterol. 2016 Nov 14;22(42):9288-9299. Review.

September 2016. Biomarkers for colitis-associated colorectal cancer. Chen R, Lai LA, Brentnall TA, Pan S. World J Gastroenterol. 2016 Sep 21;22(35):7882-91. doi: 10.3748/wjg.v22.i35.7882. Review.

September 2016. Pancreatic Cancer Chemoprevention Translational Workshop: Meeting Report. Miller MS, Allen P, Brentnall TA, Goggins M, Hruban RH, Petersen GM, Rao CV, Whitcomb DC, Brand RE, Chari ST, Klein AP, Lubman DM, Rhim AD, Simeone DM, Wolpin BM, Umar A, Srivastava S, Steele VE, Rinaudo JA. Pancreas. 2016 Sep;45(8):1080-91. doi: 10.1097/MPA.0000000000000705.

June 2016. Progress in the Earlier Detection of Pancreatic Cancer. Brentnall TA. J Clin Oncol. 2016 Jun 10;34(17):1973-4. doi: 10.1200/JCO.2016.66.5265. Epub 2016 Apr 25.

December 2015. Combining in Vitro Diagnostics with in Vivo Imaging for Earlier Detection of Pancreatic Ductal Adenocarcinoma: Challenges and Solutions. Laeseke PF, Chen R, Jeffrey RB, Brentnall TA, Willmann JK. Radiology. 2015 Dec;277(3):644-61. doi: 10.1148/radiol.2015141020.

August 2015. Proteomics analysis of bodily fluids in pancreatic cancer. Pan S, Brentnall TA, Chen R. Proteomics. 2015 Aug;15(15):2705-15. doi: 10.1002/pmic.201400476. Epub 2015 Apr 27.

July 2015. Early Detection of Sporadic Pancreatic Cancer: Summative Review. Chari ST, Kelly K, Hollingsworth MA, Thayer SP, Ahlquist DA, Andersen DK, Batra SK, Brentnall TA, Canto M, Cleeter D, Firpo MA, Gambhir SS, Go VL, Hines OJ, Kenner BJ, Klimstra DS, Lerch MM, Levy MJ, Maitra A, Mulvihill SJ, Petersen GM, Rhim AD, Simeone DM, Srivastava S, Tanaka M, Vinik AI, Wong D. Pancreas. 2015 Jul;44(5):693-712. doi: 10.1097/MPA.0000000000000368.

March 2015. Vascular Endothelial Growth Factor Receptor Type 2-targeted Contrast-enhanced US of Pancreatic Cancer Neovasculature in a Genetically Engineered Mouse Model: Potential for Earlier Detection. Pysz MA, Machtaler SB, Seeley ES, Lee JJ, Brentnall TA, Rosenberg J, Tranquart F, Willmann JK. Radiology. 2015 Mar;274(3):790-9. doi: 10.1148/radiol.14140568. Epub 2014 Oct 14.

January 2015. Proteins associated with pancreatic cancer survival in patients with resectable pancreatic ductal adenocarcinoma. Chen R, Dawson DW, Pan S, Ottenhof NA, de Wilde RF, Wolfgang CL, May DH, Crispin DA, Lai LA, Lay AR, Waghray M, Wang S, McIntosh MW, Simeone DM, Maitra A, Brentnall TA. Lab Invest. 2015 Jan;95(1):43-55. doi: 10.1038/labinvest.2014.128. Epub 2014 Oct 27.

December 2014. Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer. Chen R, Pan S, Lai K, Lai LA, Crispin DA, Bronner MP, Brentnall TA. World J Gastroenterol. 2014 Dec 7;20(45):17037-48. doi: 10.3748/wjg.v20.i45.17037.

March 2014. Quantitative Glycoproteomics Analysis Reveals Changes in N-Glycosylation Level Associated with Pancreatic Ductal Adenocarcinoma. Pan S, Chen R, Tamura Y, Crispin DA, Lai LA, May DH, McIntosh MW, Goodlett DR, Brentnall TA. J Proteome Res. 2014 Mar 7;13(3):1293-306. doi: 10.1021/pr4010184. Epub 2014 Jan 28.

February 2014. Response. Risques RA, Ussakli C, Salk JJ, Rabinovitch PS, Brentnall TA. J Natl Cancer Inst. 2014 Feb;106(2):djt437. doi: 10.1093/jnci/djt437. Epub 2014 Jan 8.

November 2013. Clonal Expansions and Short Telomeres Are Associated with Neoplasia in Early-onset, but not Late-onset, Ulcerative Colitis. Salk JJ, Bansal A, Lai LA, Crispin DA, Ussakli CH, Horwitz MS, Bronner MP, Brentnall TA, Loeb LA, Rabinovitch PS, Risques RA. Inflamm Bowel Dis. 2013 Nov;19(12):2593-602. doi: 10.1097/MIB.0b013e3182a87640.

November 2013. Unexpected gain of function for the scaffolding protein plectin due to mislocalization in pancreatic cancer. Shin SJ, Smith JA, Rezniczek GA, Pan S, Chen R, Brentnall TA, Wiche G, Kelly KA. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19414-9. doi: 10.1073/pnas.1309720110. Epub 2013 Nov 11.

October 2013. Detection of Pancreatic Ductal Adenocarcinoma in Mice by Ultrasound Imaging of Thymocyte Differentiation Antigen 1. Foygel K, Wang H, Machtaler S, Lutz AM, Chen R, Pysz M, Lowe AW, Tian L, Carrigan T, Brentnall TA, Willmann JK. Gastroenterology. 2013 Oct;145(4):885-894.e3. doi: 10.1053/j.gastro.2013.06.011. Epub 2013 Jun 18.

October 2013. Family History of Diabetes and Pancreatic Cancer as Risk Factors for Pancreatic Cancer: The PACIFIC Study. Austin MA, Kuo E, Van Den Eeden SK, Mandelson MT, Brentnall TA, Kamineni A, Potter JD. Cancer Epidemiol Biomarkers Prev. 2013 Oct;22(10):1913-1917. Epub 2013 Aug 21.

August 2013. Clinical importance of Familial Pancreatic Cancer Registry in Japan: a report from kick-off meeting at International Symposium on Pancreas Cancer 2012. Wada K, Takaori K, Traverso LW, Hruban RH, Furukawa T, Brentnall TA, Hatori T, Sano K, Takada T, Majima Y, Shimosegawa T. J Hepatobiliary Pancreat Sci. 2013 Aug;20(6):557-66. doi: 10.1007/s00534-013-0611-5. Review.

August 2013. Mitochondria and Tumor Progression in Ulcerative Colitis. Ussakli CH, Ebaee A, Binkley J, Brentnall TA, Emond MJ, Rabinovitch PS, Risques RA. J Natl Cancer Inst. 2013 Aug 21;105(16):1239-48. doi: 10.1093/jnci/djt167. Epub 2013 Jul 12.

June 2013. Screening and surgical outcomes of familial pancreatic cancer. Templeton AW, Brentnall TA. Surg Clin North Am. 2013 Jun;93(3):629-45. doi: 10.1016/j.suc.2013.02.002. Epub 2013 Apr 13.

February 2013. Tissue proteomics in pancreatic cancer study: discovery, emerging technologies and challenges. Pan S, Brentnall TA, Kelly K, Chen R. Proteomics. 2013 Feb;13(3-4):710-21. doi: 10.1002/pmic.201200319. Epub 2013 Jan 7.

January 2013. Molecular analysis of precursor lesions in familial pancreatic cancer. Crnogorac-Jurcevic T, Chelala C, Barry S, Harada T, Bhakta V, Lattimore S, Jurcevic S, Bronner M, Lemoine NR, Brentnall TA. PLoS One. 2013;8(1):e54830. doi: 10.1371/journal.pone.0054830. Epub 2013 Jan 23.

December 2012. Prospective study of the progression of low-grade dysplasia in ulcerative colitis using current cancer surveillance guidelines. Zisman TL, Bronner MP, Rulyak S, Kowdley KV, Saunders M, Lee SD, Ko C, Kimmey MB, Stevens A, Maurer J, Brentnall TA. Inflamm Bowel Dis. 2012 Dec;18(12):2240-6. doi: 10.1002/ibd.22912. Epub 2012 Apr 16.

November 2012. Arousal of cancer-associated stromal fibroblasts: Palladin-activated fibroblasts promote tumor invasion Brentnall TA. Cell Adh Migr. 2012 Nov-Dec;6(6):488-94. doi: 10.4161/cam.21453. Epub 2012 Oct 17.

Contact Info
Education

M.D., University of Washington, Seattle, WA

Residency in Medicine, UCLA, Los Angeles, CA

Fellowship in Gastroenterology, University of Washington, Seattle, WA

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